Author

R. Chelbi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:differential expression· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Assay:ChIP-seq· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

f. Porteu· 3 shared A. Imanci· 2 shared A. Renneville· 2 shared D. Hidaoui· 2 shared D. Selimoglu-Buet· 2 shared E. Elvira-Matelot· 2 shared E. Solary· 2 shared L. Laplane· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

f. Porteu

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

CXCL8 secreted by immature granulocytes inhibits wildtype hematopoiesis in chronic myelomonocytic leukemia

P. Deschamps, M. Wacheux, A. Gosseye, M. Morabito, A. Pages, A.-M. Lyne, A. Alfaro, P. Rameau, A. Imanci, R. Chelbi, V. Marchand, A. Renneville, M. M. Patnaik, V. Lapierre, B. Badaoui, , D. Selimoglu-Buet

The paper identifies CXCL8 secreted by immature granulocytes as a factor inhibiting wildtype hematopoiesis in CMML, suggesting CXCL8 blockade could slow disease progression.

bioRxiv · Mar 8, 2024Cancer Biology

Targeting Heterochromatin Eliminates Malignant Stem Cells in Chronic Myelomonocytic Leukemia Through Reactivation of Retroelements and Innate Immune pathways

D. Hidaoui, A. Porquet, R. Chelbi, M. Bohm, A. Polizou, V. Alcazer, S. Depil, A. Imanci, M. Morabito, A. Renneville, D. Selimoglu-Buet, S. Thepot, R. Itzykson, L. Laplane, N. Droin, , F. PORTEU

This study shows that combining DNA hypomethylating agents with H3K9me2 inhibitors reactivates immune pathways and eliminates malignant stem cells in CMML by targeting heterochromatin disorganization.

bioRxiv · Feb 2, 2024Cancer Biology

Dysfunction of exocytosis causes catecholamine hypersecretion in patient with pheochromocytoma

S. Houy, L. Streit, I. Drissa, M. Rame, C. Decraene, S. Moog, L. Brunaud, J. Lanoix, R. Chelbi, F. Bihain, S. Lacomme, S. Lomazzi, M. Vix, D. Mutter, E. Paramithiotis, , S. Gasman

The paper measures catecholamine secretion and exocytic protein expression in pheochromocytoma cells to show dysfunction in calcium-regulated exocytosis leads to hypersecretion.

bioRxiv · Nov 2, 2021 · PreprintCancer Biology

The NF-κB pathway regulates heterochromatin at intronic young LINE-1 elements and hematopoietic stem cell gene expression during irradiation stress

Y. Pelinski, D. Hidaoui, A. Stolz, F. Hermetet, R. Chelbi, M. K. Diop, A. Chioukh, F. Porteu, E. Elvira-Matelot

The paper shows that ionizing radiation induces H3K9me3 loss at intronic L1Md retroelements, linked to NF-κB repression and HSC gene expression changes.

bioRxiv · Jun 8, 2021Cell Biology