Author

J. Lanoix

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

P. Thibault· 4 shared C. Durette· 2 shared C. Perreault· 2 shared J. Humeau· 2 shared J.-P. Laverdure· 2 shared K. Vincent· 2 shared M. Desjardins· 2 shared S. Gruenheid· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersImmunology

P. Thibault

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Modeling gene-environment interactions in Parkinson's Disease: Helicobacter pylori infection of Pink1-/- mice induces CD8 T cell-dependent motor and cognitive dysfunction.

A. Kazanova, J. Sung, N. L. Oliveira, C. Gavino, H. Bessaiah, J. Pei, L. Burns, W. Miller, M. Brouillard-Galipeau, L. Zhu, L. M. Guerra, M. N. Elemeery, S. J. Recinto, A. MacDonald, J. Lanoix, , S. Gruenheid

This study shows that Helicobacter pylori infection in Pink1-/- mice causes motor and cognitive dysfunction linked to CD8 T cell activity, mimicking early PD features.

bioRxiv · Feb 25, 2024 · PreprintImmunology

Transposable elements regulate thymus development and function

J.-D. Larouche, C. M. Laumont, A. Trofimov, K. Vincent, L. Hesnard, S. Brochu, C. Cote, J. Humeau, E. Bonneil, J. Lanoix, C. Durette, P. Gendron, J.-P. Laverdure, E. R. Richie, S. Lemieux, , C. Perreault

This study investigates the role of transposable elements in thymus development and function, showing their interactions with transcription factors and their impact on T-cell tolerance.

bioRxiv · Jul 12, 2023Immunology

LRRK2 regulates the activation of the unfolded protein response and antigen presentation in macrophages during inflammation

A. M. Fahmy, T. Cannon, C. H. Paredes, A. Ahmadi, Y. Z. Xu, B. Barette, M. Ibrahim, J. Lanoix, G. Arango-Duque, E. Schurr, E. Chevet, P. Thibault, S. Gruenheid, H. McBride, M. Desjardins

This study identifies LRRK2 as a regulator of the unfolded protein response and antigen presentation in macrophages during inflammation, linking it to immune response mechanisms.

bioRxiv · Jun 14, 2023 · PreprintImmunology

Autophagy degrades immunogenic endogenous retroelements induced by 5-azacytidine in acute myeloid leukemia

N. Noronha, C. Durette, B. E Silva, J. Courtois, J. Humeau, A. Sauvat, M.-P. Hardy, K. Vincent, J.-P. Laverdure, J. Lanoix, F. Baron, P. Thibault, C. Perreault, G. Ehx

This study shows that 5-azacytidine induces endogenous retroelement transcripts in AML cells, which are degraded by autophagy and not presented as MHC-I peptides, and that autophagy inhibition enhances immune responses.

bioRxiv · Dec 2, 2022Immunology

Dysfunction of exocytosis causes catecholamine hypersecretion in patient with pheochromocytoma

S. Houy, L. Streit, I. Drissa, M. Rame, C. Decraene, S. Moog, L. Brunaud, J. Lanoix, R. Chelbi, F. Bihain, S. Lacomme, S. Lomazzi, M. Vix, D. Mutter, E. Paramithiotis, , S. Gasman

The paper measures catecholamine secretion and exocytic protein expression in pheochromocytoma cells to show dysfunction in calcium-regulated exocytosis leads to hypersecretion.

bioRxiv · Nov 2, 2021 · PreprintCancer Biology