Author

R. D. Leapman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Assay:electronic health records· 3 Approach:experimental assay· 2 Approach:deep learning· 1 Organism:human· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1

Frequent Co-Authors

G. Zhang· 3 shared M. A. Aronova· 3 shared A. B. Anderson· 1 shared A. Fera· 1 shared A. L. Notkins· 1 shared A. Rao· 1 shared B. Storrie· 1 shared C. Byrnes· 1 shared

Activity by Year

2019-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersBiophysics

G. Zhang

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Author profile →

4 papers

Recent·Most cited

Dense cellular segmentation for EM using 2D-3D neural network ensembles

M. D. Guay, Z. A. S. Emam, A. B. Anderson, M. A. Aronova, B. Storrie, I. D. Pokrovskaya, R. D. Leapman

The paper introduces 2D-3D neural network ensembles for dense cellular segmentation in EM images, achieving accuracy comparable to human annotators.

bioRxiv · Jan 5, 2020Cell Biology

Use of dual electron probes reveals role of ferritin in erythropoiesis

M. A. Aronova, S. J. Noh, G. Zhang, C. Byrnes, E. R. Meier, Y. C. Kim, R. D. Leapman

The paper uses dual electron probes to study ferritin distribution in human erythropoietic stem cells during differentiation, finding increased Fe3+ accumulation in lysosomal ferritin cores.

bioRxiv · Dec 19, 2019Cell Biology

Quantitative method for estimating stain density in electron microscopy of conventionally prepared biological specimens

A. Fera, Q. He, G. Zhang, R. D. Leapman

The paper introduces a method to estimate stain density in electron microscopy by using bright-field intensity ratios and section thickness measurements.

bioRxiv · Dec 11, 2019Biophysics

Determination of secretory granule maturation times in pancreatic islet beta-cells by serial block face scanning electron microscopy

A. Rao, E. L. McBride, G. Zhang, T. Cai, A. L. Notkins, M. A. Aronova, R. D. Leapman

The paper uses SBEM to determine secretory granule maturation times in mouse pancreatic beta-cells, finding immature granules remain in their state for about 2 hours before transforming.

bioRxiv · Dec 5, 2019Biophysics