Author

R. D. Morgan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:protein structure prediction· 2 Approach:statistical model· 2 Assay:structural biology· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

D. M. Picton· 2 shared J. C. D. Hinton· 2 shared S. C. Went· 2 shared T. R. Blower· 2 shared A. Nelson· 1 shared B. C. McGeough· 1 shared B. L. Stoddard· 1 shared B. W. Shen· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersMicrobiology

D. M. Picton

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Structure and rational engineering of the PglX methyltransferase and specificity factor for BREX phage defence

S. C. Went, D. M. Picton, R. D. Morgan, A. Nelson, D. T. Dryden, D. L. Smith, N. Wenner, J. C. D. Hinton, T. R. Blower

The paper characterizes the BREX system in Salmonella, determines the structure of PglX, and shows how rational engineering expands phage targeting and host motif methylation.

bioRxiv · Apr 12, 2024Microbiology

A widespread family of WYL-domain transcriptional regulators co-localises with diverse phage defence systems and islands

D. M. Picton, J. D. Harling-Lee, S. J. Duffner, S. C. Went, R. D. Morgan, J. C. D. Hinton, T. R. Blower

The paper identifies BrxR, a WYL-domain transcriptional regulator that represses phage defence systems and is widespread among bacteria, often co-localized with defence islands.

bioRxiv · Dec 19, 2021 · PreprintMicrobiology

Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme visualized by CryoEM

B. W. Shen, J. D. Quispe, Y. Luyten, B. C. McGeough, R. D. Morgan, B. L. Stoddard

This study visualizes how a bifunctional restriction-modification enzyme coordinates DNA methylation and cleavage using CryoEM, revealing the structural basis for its dual function.

bioRxiv · Jan 6, 2021Biochemistry