Author

D. M. Picton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 3 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Assay:structural biology· 2 Research Focus:cell type annotation· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

J. C. D. Hinton· 3 shared T. R. Blower· 3 shared N. Wenner· 2 shared R. D. Morgan· 2 shared S. C. Went· 2 shared A. Ali· 1 shared A. Beckett· 1 shared A. Bowers-Barnard· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersMicrobiology

J. C. D. Hinton

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4 papers

Recent·Most cited

Structure and rational engineering of the PglX methyltransferase and specificity factor for BREX phage defence

S. C. Went, D. M. Picton, R. D. Morgan, A. Nelson, D. T. Dryden, D. L. Smith, N. Wenner, J. C. D. Hinton, T. R. Blower

The paper characterizes the BREX system in Salmonella, determines the structure of PglX, and shows how rational engineering expands phage targeting and host motif methylation.

bioRxiv · Apr 12, 2024Microbiology

A widespread family of WYL-domain transcriptional regulators co-localises with diverse phage defence systems and islands

D. M. Picton, J. D. Harling-Lee, S. J. Duffner, S. C. Went, R. D. Morgan, J. C. D. Hinton, T. R. Blower

The paper identifies BrxR, a WYL-domain transcriptional regulator that represses phage defence systems and is widespread among bacteria, often co-localized with defence islands.

bioRxiv · Dec 19, 2021 · PreprintMicrobiology

Evasion of Toll-like Receptor Recognition by Escherichia coli is mediated via Population Level Regulation of Flagellin Production

M. Lanz, C. M. Birchall, L. K. Drage, D. M. Picton, C. Mowbray, Q. Alsenani, A. M. Z. Tan, A. Ali, C. Harding, R. Pickard, J. Hall, P. D. Aldridge

This study shows that uropathogenic E. coli evades TLR5 recognition by regulating flagellin production at the population level, not through antigenic variation.

bioRxiv · Nov 18, 2021 · PreprintMicrobiology

Isolation and characterisation of bacteriophages with activity against invasive non-typhoidal Salmonella causing bloodstream infection in Malawi

E. V. Rodwell, N. Wenner, C. V. Pulford, Y. Cai, A. Bowers-Barnard, A. Beckett, J. Rigby, D. M. Picton, T. R. Blower, N. A. Feasey, J. C. D. Hinton, B. M. Perez-Sepulveda

This study isolates and characterizes bacteriophages active against invasive non-typhoidal Salmonella causing bloodstream infections in Malawi, identifying three phylogenetic clusters with varying host ranges.

bioRxiv · Feb 18, 2021Microbiology