J. C. D. Hinton

Temporal profiling of Salmonella transcriptional dynamics during macrophage infection using a comprehensive reporter library

This study uses a GFP-reporter library to profile Salmonella transcriptional dynamics during macrophage infection, revealing condition-specific regulation and novel gene activity.

Salmonella succinate utilisation is inhibited by multiple regulatory systems

This study identifies multiple RpoS-independent regulatory systems that inhibit Salmonella's succinate utilisation, revealing redundant mechanisms controlling carbon metabolism during infection.

Genome-wide fitness analysis identifies genes required for in vitro growth and macrophage infection by African and Global Epidemic pathovariants of Salmonella Enteritidis

This study uses transposon insertion sequencing to identify genes required for growth and macrophage infection in African and Global Epidemic S. Enteritidis, finding shared and strain-specific virulence factors.

An accessible, efficient and global approach for the large-scale sequencing of bacterial genomes

The paper describes a low-cost, efficient pipeline for large-scale bacterial genome sequencing, demonstrating its application in collecting and sequencing 10,419 isolates from multiple countries.

A widespread family of WYL-domain transcriptional regulators co-localises with diverse phage defence systems and islands

The paper identifies BrxR, a WYL-domain transcriptional regulator that represses phage defence systems and is widespread among bacteria, often co-localized with defence islands.

Biogenesis of a bacterial metabolosome for propanediol utilization

This study investigates the biogenesis of propanediol-utilization metabolosomes in bacteria, revealing both 'Shell first' and 'Cargo first' assembly pathways.

Distinct cell death pathways induced by granzymes collectively protect against intestinal Salmonella infection

This study shows that granzymes A and B use distinct cell death pathways to protect against intestinal Salmonella infection by balancing bacterial growth and translocation.

Scanning mutagenesis of RNA-binding protein ProQ reveals a quality control role for the Lon protease

This study identifies ProQ residues critical for function and reveals that Lon protease mediates quality control of ProQ and Hfq by degrading non-functional RNA-binding proteins.

Isolation and characterisation of bacteriophages with activity against invasive non-typhoidal Salmonella causing bloodstream infection in Malawi

This study isolates and characterizes bacteriophages active against invasive non-typhoidal Salmonella causing bloodstream infections in Malawi, identifying three phylogenetic clusters with varying host ranges.

Niche-specific profiling reveals transcriptional adaptations required for the cytosolic lifestyle of Salmonella enterica

This study identifies niche-specific transcriptional adaptations in Salmonella enterica for cytosolic and vacuolar lifestyles using RNA-seq and microscopy.

Prophage-encoded phage defence proteins with cognate self-immunity

The paper identifies BstA, a prophage-encoded phage defense protein that suppresses phage epidemics through abortive infection, with self-immunity mediated by the anti-BstA element.

A window into lysogeny: Revealing temperate phage biology with transcriptomics

The paper uses bacterial RNA-seq data to identify novel prophage accessory loci by analyzing transcriptional landscapes of Salmonella prophages.

African Salmonella Typhimurium sequence type 313 lineage 2 evades MAIT cell recognition by overexpressing RibB

The paper shows African S. Typhimurium lineage 2 strains evade MAIT cell recognition by overexpressing ribB, which may contribute to their pathogenicity.

The fitness landscape of the African Salmonella Typhimurium ST313 strain D23580 reveals unique properties of the pBT1 plasmid

The paper uses transposon insertion sequencing to analyze the fitness landscape of Salmonella Typhimurium ST313 strain D23580, identifying essential genes and plasmid-encoded factors affecting growth and macrophage infection.

The diversity, evolution and ecology of Salmonella in venomous snakes

This study investigates Salmonella diversity in venomous snakes, finding 91% prevalence and identifying metabolic differences between subspecies, suggesting a potential role in human Salmonellosis in Africa.

The primary transcriptome, small RNAs, and regulation of antimicrobial resistance in Acinetobacter baumannii

This study identifies transcriptome architecture and small RNAs in Acinetobacter baumannii, revealing regulatory mechanisms and antimicrobial resistance traits.

Salmonella enterica Serovar Typhimurium ST313 Responsible For Gastroenteritis In The UK Are Genetically Distinct From Isolates Causing Bloodstream Infections In Africa

This paper identifies genetically distinct ST313 Salmonella isolates causing gastroenteritis in the UK and invasive disease in Africa, highlighting their evolutionary divergence and adaptation to different environments.