Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer
R. Delaine-Smith, E. Maniati, B. Malacrida, S. Nichols, R. Roozitalab, R. R. Jones, L. Lecker, O. M. Pearce, M. M. Knight, F. R. Balkwill
The paper models how TGFβR and Hh pathways regulate ECM molecules in ovarian cancer using tri-culture models and identifies inhibitor combinations that reduce fibroblast activation and ECM remodeling.
bioRxiv · Feb 1, 2021Cancer Biology