Author

S. Nichols

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

C. Graham· 2 shared L. Pongor· 2 shared L. Sciuto· 2 shared M. Abel· 2 shared M. Nirula· 2 shared N. Takahashi· 2 shared R. Kumar· 2 shared A. Apolo· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersCancer Biology

C. Graham

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Author profile →

4 papers

Recent·Most cited

Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities

P. A. Desai, N. Takahashi, R. Kumar, S. Nichols, J. Malin, A. Hunt, C. Schultz, Y. Cao, D. Tillo, D. Nousome, L. Chauhan, L. Sciuto, K. Jordan, V. Rajapakse, D. Lissa, , R. El Meskini

This study maps the SCLC tumor microenvironment and identifies cancer-associated fibroblasts as key drivers of neuroendocrine state plasticity and poor prognosis.

bioRxiv · Feb 9, 2024Cancer Biology

Direct Cryo-ET observation of platelet deformation induced by SARS-CoV-2 Spike protein

C. C. Kuhn, N. Basnet, S. Bodakuntla, P. Alvarez- Brecht, S. Nichols, A. Martinez-Sanchez, L. Agostini, Y.-M. Soh, J. Takagi, C. Biertumpfel, N. Mizuno

This study observes SARS-CoV-2 Spike protein-induced platelet deformation and activation using cryo-ET and live imaging, identifying integrin vβ3 as a binding target.

bioRxiv · Nov 22, 2022Cell Biology

Subtyping of Small Cell Lung Cancer using plasma cell-free nucleosomes

G. Fialkoff, N. Takahashi, I. Sharkia, J. Gutin, N. Hermoni, R. Kumar, L. Pongor, S. Nichols, L. Sciuto, C. Graham, P. Desai, M. Nirula, P. Suresh, M. Abel, R. Elmeskini, , A. Thomas

This study uses cfChIP-seq on plasma samples to subtype SCLC based on epigenetic states, linking plasma nucleosome data to tumor transcriptomes and developing a classifier for lineage-defining transcription factors.

bioRxiv · Jun 24, 2022 · PreprintCancer Biology

Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer

R. Delaine-Smith, E. Maniati, B. Malacrida, S. Nichols, R. Roozitalab, R. R. Jones, L. Lecker, O. M. Pearce, M. M. Knight, F. R. Balkwill

The paper models how TGFβR and Hh pathways regulate ECM molecules in ovarian cancer using tri-culture models and identifies inhibitor combinations that reduce fibroblast activation and ECM remodeling.

bioRxiv · Feb 1, 2021Cancer Biology