Ammonia inhibits energy metabolism in astrocytes in a rapid and GDH2-dependent manner
L. Drews, M. Zimmermann, R. E. Poss, D. Brilhaus, L. Bergmann, C. Wiek, R. P. Piekorz, A. P. M. Weber, T. Mettler-Altmann, A. S. Reichert
The paper shows ammonia inhibits astrocyte energy metabolism via GDH2-dependent mechanisms, disrupting mitochondrial respiration and the TCA cycle under hyperammonemia.
bioRxiv · Jun 28, 2019Biochemistry