Author

R. P. Piekorz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

M. R. Ahmadian· 4 shared A. Lang· 3 shared J. Scheller· 3 shared A. S. Reichert· 2 shared C. Wiek· 2 shared L. Bergmann· 2 shared M. Mehrabipour· 2 shared P. Verhuelsdonk· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersBiochemistry

M. R. Ahmadian

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Identification of SIRT4 as a novel paralog-specific interactor and candidate suppressor of C-RAF kinase in MAPK signaling

M. Mehrabipour, R. Dvorsky, S. Nakhaei-Rad, A. Lang, P. Verhuelsdonk, M. R. Ahmadian, R. P. Piekorz

This study identifies SIRT4 as a specific interactor of C-RAF kinase, showing it suppresses MAPK signaling by stabilizing the inactive form of C-RAF.

bioRxiv · Nov 23, 2023 · PreprintBiochemistry

CoCl2 triggered pseudohypoxic stress induces proteasomal degradation of SIRT4 via polyubiquitination of lysines K78 and K299

N. Hampel, J. Georgy, M. Mehrabipour, A. Lang, J. Scheller, M. R. Ahmadian, D. M. Floss, R. P. Piekorz

This study shows CoCl2 induces SIRT4 degradation through proteasomal polyubiquitination at K78 and K299, and via autophagy/mitophagy.

bioRxiv · May 16, 2023 · PreprintBiochemistry

Alteration of myocardial structure and function in RAF1associated Noonan syndrome: Insights from cardiac disease modeling based on patient-derived iPSCs

S. Nakhaei-Rad, F. Bazgir, J. Dahlmann, A. V. Busley, M. Buchholzer, F. Haghighi, A. Schaenzer, A. Hahn, S. Koetter, D. Schanze, R. Anand, F. Funk, A. Borchardt, A. V. Kronenbitter, J. Scheller, , M. R. Ahmadian

This study uses patient-derived iPSCs to model RAF1-associated Noonan syndrome and identifies sarcomere structural abnormalities linked to cardiac dysfunction.

bioRxiv · Jan 22, 2022 · PreprintCell Biology

Subcellular localization and mitotic interactome analyses identify SIRT4 as a centrosomally localized and microtubule associated protein

L. Bergmann, A. Lang, C. Bross, S. Altinoluk-Hambuechen, I. Fey, N. Overbeck, A. Stefanski, C. Wiek, P. Verhuelsdonk, C. Mielke, D. Sohn, K. Stühler, H. Hanenberg, R. U. Jänicke, J. Scheller, , R. P. Piekorz

This study identifies SIRT4 as a centrosomal and microtubule-associated protein that delays mitotic progression and reduces cell proliferation.

bioRxiv · Feb 17, 2020Cell Biology

Ammonia inhibits energy metabolism in astrocytes in a rapid and GDH2-dependent manner

L. Drews, M. Zimmermann, R. E. Poss, D. Brilhaus, L. Bergmann, C. Wiek, R. P. Piekorz, A. P. M. Weber, T. Mettler-Altmann, A. S. Reichert

The paper shows ammonia inhibits astrocyte energy metabolism via GDH2-dependent mechanisms, disrupting mitochondrial respiration and the TCA cycle under hyperammonemia.

bioRxiv · Jun 28, 2019Biochemistry