A. S. Reichert

Mitochondrial Apolipoprotein MIC26 is a metabolic rheostat regulating central cellular fuel pathways

The paper shows MIC26 regulates metabolic pathways by modulating mitochondrial metabolite exchange, with its role reversing under hyperglycemia.

MIC13 and SLP2 seed the assembly of MIC60-subcomplex to facilitate crista junction formation

This study identifies SLP2 as an auxiliary MICOS subunit that interacts with MIC13 to seed MIC60 assembly and promote crista junction formation.

Live-cell super-resolution nanoscopy reveals modulation of cristae dynamics in bioenergetically compromised mitochondria

The paper uses live-cell nanoscopy to study cristae dynamics under various bioenergetic conditions and finds that cristae remodeling is independent of mitochondrial membrane potential but affected by ADP/ATP exchange.

4EBP1/2 support tumorigenicity and cell survival during energetic stress by translationally regulating fatty acid synthesis

This study shows 4EBP1/2 promote cell survival under glucose starvation by repressing fatty acid synthesis and maintaining redox balance, supporting tumorigenicity in cancer cells.

JNK signalling regulates self-renewal of proliferative urine-derived renal progenitor cells via inhibition of ferroptosis

This study shows JNK signaling supports self-renewal of urine-derived renal progenitor cells by preventing ferroptosis, suggesting its role in kidney disease modeling.

Protease OMA1 Modulates Mitochondrial Bioenergetics and Ultrastructure through Dynamic Association with MICOS Complex

This study identifies OMA1's role in maintaining mitochondrial ultrastructure and bioenergetics through its interaction with the MICOS complex, showing its importance in cellular stress responses and apoptosis.

Subcellular localization and mitotic interactome analyses identify SIRT4 as a centrosomally localized and microtubule associated protein

This study identifies SIRT4 as a centrosomal and microtubule-associated protein that delays mitotic progression and reduces cell proliferation.

Ammonia inhibits energy metabolism in astrocytes in a rapid and GDH2-dependent manner

The paper shows ammonia inhibits astrocyte energy metabolism via GDH2-dependent mechanisms, disrupting mitochondrial respiration and the TCA cycle under hyperammonemia.

Cristae undergo continuous cycles of fusion and fission in a MICOS-dependent manner

The paper uses live-cell imaging to show mitochondrial cristae undergo continuous fusion and fission, dependent on MIC13, with dynamics similar to crista junctions.