Selective Targeting of Ras Mutant Cancers via a New Small Molecule
B. Tolani, A. Celli, Y. Yao, Y. Z. Tan, R. Fetter, C. R. Liem, A. J. de Smith, T. Vasanthakumar, P. Bisignano, I. B. Seiple, J. L. Rubinstein, M. Jost, J. S. Weissman
This paper identifies 249C as a small molecule that selectively targets Ras-mutant cancers by inhibiting V-ATPase, disrupting lysosomal acidification and key survival pathways in Ras-driven tumors.
bioRxiv · Dec 23, 2020Cancer Biology