Author

I. B. Seiple

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Cancer Biology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

A. A. Tran· 1 shared A. Celli· 1 shared A. D. Cotton· 1 shared A. D. Ramirez· 1 shared A. J. de Smith· 1 shared A. K. Ecker· 1 shared A. R. McColloch· 1 shared B. Faust· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperBioengineering

A. A. Tran

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase

R. E. Diaz, A. K. Ecker, G. J. Correy, P. Asthana, I. D. Young, B. Faust, M. C. Thompson, I. B. Seiple, S. J. Van Dyken, R. M. Locksley, J. S. Fraser

This study characterizes the pH-specific enzymatic activity and ligand binding of mouse AMCase using structural and computational methods, revealing dual activity optima at pH 2 and 7.

bioRxiv · Jun 3, 2023Biochemistry

Label-retention expansion microscopy

X. Shi, Q. Li, Z. Dai, A. A. Tran, S. Feng, A. D. Ramirez, Z. Lin, X. Wang, T. T. Chow, J. Chen, D. Kumar, A. R. McColloch, J. F. Reiter, E. J. Huang, I. B. Seiple, B. Huang

This paper introduces label-retention expansion microscopy (LR-ExM) to prevent fluorescence signal loss and enable high-efficiency labeling, achieving molecular resolution in visualizing clathrin-coated pits.

bioRxiv · Mar 4, 2021Bioengineering

Selective Targeting of Ras Mutant Cancers via a New Small Molecule

B. Tolani, A. Celli, Y. Yao, Y. Z. Tan, R. Fetter, C. R. Liem, A. J. de Smith, T. Vasanthakumar, P. Bisignano, I. B. Seiple, J. L. Rubinstein, M. Jost, J. S. Weissman

This paper identifies 249C as a small molecule that selectively targets Ras-mutant cancers by inhibiting V-ATPase, disrupting lysosomal acidification and key survival pathways in Ras-driven tumors.

bioRxiv · Dec 23, 2020Cancer Biology

Examining gender imbalance in chemistry authorship

A. D. Cotton, I. B. Seiple

This study analyzes gender representation in chemistry authorship using PubMed data from 2005 to 2023, finding persistent male overrepresentation and variability across journals.

bioRxiv · Jul 8, 2020Scientific Communication & Education