Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
S. Aiyer, P. R. Baldwin, S. M. Tan, Z. Shan, J. Oh, A. Mehrani, M. E. Bowman, G. Louie, D. O. Passos, S. Đorđevic-Marquardt, M. Mietzsch, J. A. Hull, S. Hoshika, B. A. Barad, D. Grotjahn, , D. Lyumkis
This study improves cryo-EM data collection by reducing resolution attenuation during stage tilt, enabling isotropic map reconstruction of specimens with preferred orientations.
bioRxiv · Jul 14, 2023Biophysics
Y. Z. Tan, K. A. Keon, R. Abdelaziz, P. Imming, W. Schulze, K. Schumacher, J. L. Rubinstein
This study determines the structure of plant V-ATPase from citrus fruit using SidK purification, revealing its ATP:H+ ratio and structural differences from yeast and mammalian enzymes.
bioRxiv · May 1, 2022Biochemistry
Y. Z. Tan, Y. M. Abbas, J. Z. Wu, D. Wu, G. G. Hesketh, S. A. Bueler, A.-C. Gingras, C. V. Robinson, S. Grinstein, J. L. Rubinstein
The paper uses cryoEM to study endogenous V-ATPase interactions with mEAK-7 in porcine kidney, revealing structural insights and functional differences compared to yeast.
bioRxiv · Nov 3, 2021Biochemistry
B. Tolani, A. Celli, Y. Yao, Y. Z. Tan, R. Fetter, C. R. Liem, A. J. de Smith, T. Vasanthakumar, P. Bisignano, I. B. Seiple, J. L. Rubinstein, M. Jost, J. S. Weissman
This paper identifies 249C as a small molecule that selectively targets Ras-mutant cancers by inhibiting V-ATPase, disrupting lysosomal acidification and key survival pathways in Ras-driven tumors.
bioRxiv · Dec 23, 2020Cancer Biology
This paper introduces a high-speed cryoEM specimen preparation method that reduces blotting times and improves ice film quality for cryoEM imaging.
Acta Crystallographica Section D Structural Biology · Oct 13, 2020Peer-reviewedBiophysics
H. Guo, E. Franken, Y. Deng, S. Benlekbir, G. Singla Lezcano, B. Janssen, L. Yu, Z. A. Ripstein, Y. Z. Tan, J. L. Rubinstein
The paper introduces EER data format for cryoEM DDD movies, preserving spatial and temporal resolution without increasing file size.
bioRxiv · Apr 28, 2020Biophysics
Y. Z. Tan, L. Zhang, J. Rodrigues, R. B. Zheng, S. I. Giacometti, A. L. Rosario, B. Kloss, V. P. Dandey, H. Wei, R. Brunton, A. M. Raczkowski, D. Athayde, M. J. Catalao, M. Pimentel, O. B. Clarke, , F. Mancia
The paper presents the cryo-EM structure of AftD from M. abscessus and shows its interaction with ACP, revealing potential regulatory mechanisms.
bioRxiv · Dec 22, 2019Biochemistry
Y. Z. Tan, S. Aiyer, M. Mietzsch, J. A. Hull, R. McKenna, J. Grieger, R. J. Samulski, T. S. Baker, M. Agbandje-McKenna, D. Lyumkis
The paper improves cryo-EM resolution by correcting Ewald sphere curvature, achieving 1.86 Å resolution for an AAV2 variant.
Nature Communications · Sep 7, 2018Peer-reviewedBiophysics
A. J. Noble, V. P. Dandey, H. Wei, J. Brasch, J. Chase, P. Acharya, Y. Z. Tan, Z. Zhang, L. Y. Kim, G. Scapin, M. Rapp, E. T. Eng, W. J. Rice, A. Cheng, C. J. Negro, , B. Carragher
This study uses fiducial-less tomography to analyze cryoEM grids and finds that 90% of particles are adsorbed to air-water interfaces, impacting protein structure and single particle analysis.
bioRxiv · Dec 11, 2017Biophysics