Author

C. R. Liem

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:flow cytometry· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

J. S. Weissman· 2 shared M. Jost· 2 shared A. Celli· 1 shared A. J. de Smith· 1 shared B. Tolani· 1 shared I. B. Seiple· 1 shared J. L. Rubinstein· 1 shared M. A. Horlbeck· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

J. S. Weissman

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Author profile →

2 papers

Recent·Most cited

Selective Targeting of Ras Mutant Cancers via a New Small Molecule

B. Tolani, A. Celli, Y. Yao, Y. Z. Tan, R. Fetter, C. R. Liem, A. J. de Smith, T. Vasanthakumar, P. Bisignano, I. B. Seiple, J. L. Rubinstein, M. Jost, J. S. Weissman

This paper identifies 249C as a small molecule that selectively targets Ras-mutant cancers by inhibiting V-ATPase, disrupting lysosomal acidification and key survival pathways in Ras-driven tumors.

bioRxiv · Dec 23, 2020Cancer Biology

High-content Imaging-based Pooled CRISPR Screens in Mammalian Cells

X. Yan, N. Stuurman, S. A. Ribeiro, M. E. Tanenbaum, M. A. Horlbeck, C. R. Liem, M. Jost, J. S. Weissman, R. Vale

The paper develops an imaging-based CRISPR screening method called optical enrichment to identify genes affecting nuclear size, identifying 14 hits from 6092 sgRNAs.

bioRxiv · Jun 30, 2020Cell Biology