BiochemistrybioRxiv
Proteasome-Bound UCH37 Debranches Ubiquitin Chains to Promote Degradation
K. K. Deol, S. O. Crowe, J. Du…·E. R. Strieter
This study identifies UCH37 as a debranching deubiquitinase that promotes proteasomal degradation by cleaving K48 branched ubiquitin chains.
DOI 10.1016/j.molcel.2020.10.017