K. K. Deol

Small molecule correctors divert CFTR-F508del from ERAD by stabilizing sequential folding states

The paper identifies molecular machinery underlying CFTR-F508del ERAD and shows correctors stabilize RNF5-resistant folding states.

A genome-wide CRISPR screen implicates plasma membrane asymmetry in exogenous C6-ceramide toxicity

This study uses a CRISPR screen to identify genetic factors affecting cancer cell resistance to C6-ceramide, revealing a role for plasma membrane asymmetry in ceramide toxicity.

Parallel CRISPR-Cas9 screens reveal mechanisms of PLIN2 and lipid droplet regulation

The paper uses CRISPR-Cas9 screens to identify genes regulating PLIN2 and lipid droplet abundance, revealing new mechanisms and creating a resource for lipid metabolism research.

Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability in cancer

The paper identifies LRP8 as a ferroptosis resistance factor in cancer, showing that its loss causes ribosome stalling during GPX4 translation, exposing a vulnerability in cancer cells.

A Cryptic K48 Ubiquitin Chain Binding Site on UCH37 is Required for its Role in Proteasomal Degradation

Proteasome-Bound UCH37 Debranches Ubiquitin Chains to Promote Degradation

This study identifies UCH37 as a debranching deubiquitinase that promotes proteasomal degradation by cleaving K48 branched ubiquitin chains.