R. H. Kirkegaard

The Parkinson's drug entacapone disrupts gut microbiome homeostasis via iron sequestration

This study shows that the Parkinson's drug entacapone disrupts gut microbiome homeostasis by sequestering iron, affecting microbial metabolism and promoting iron-scavenging organisms with resistance genes.

Characterizing the growing microorganisms at species level in 46 anaerobic digesters at Danish wastewater treatment plants: A six-year survey on microbiome structure and key drivers

This study characterizes the microbial communities in 46 anaerobic digesters over six years, identifying key drivers shaping microbiome structure and highlighting the role of immigration in bacterial diversity.

Connecting structure to function with the recovery of over 1000 high-quality activated sludge metagenome-assembled genomes encoding full-length rRNA genes using long-read sequencing

The paper uses long-read sequencing to recover over 1000 high-quality MAGs from wastewater treatment plants, enabling linkage of microbial community structure to function.

Genomic and kinetic analysis of novel Nitrospinae enriched by cell sorting

The paper isolates and characterizes two new Nitrospinae genera from marine environments, revealing differences in nitrite affinity and metabolic capabilities.

Cultivation and genomic analysis of Candidatus Nitrosocaldus islandicus, a novel obligately thermophilic ammonia-oxidizing Thaumarchaeon

This paper describes the cultivation and genomic analysis of a novel thermophilic ammonia-oxidizing Thaumarchaeon, revealing unique metabolic and genomic features.

Identifying the abundant and active microorganisms common to full scale anaerobic digesters

The paper identifies abundant and active microorganisms in full-scale anaerobic digesters by analyzing microbial communities over six years using 16S rRNA sequencing.