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22 papers
Recent·Most cited
Q. Xia, H. A. Perera, R. Bolarinho, Z. A. Piskulich, Z. Guo, J. Yin, H. He, M. Li, X. Ge, Q. Cui, O. Ramstrom, M. Yan, J.-X. Cheng
This paper demonstrates click-free imaging of carbohydrate trafficking in live cells using azido photothermal probes, revealing trehalose recycling and protein interactions in mycobacteria and other organisms.
bioRxiv · Mar 8, 2024Cell Biology
F. C. Pereira, X. Ge, J. M. Kristensen, R. H. Kirkegaard, K. Maritsch, Y. Zu, M. Decorte, B. Hausmann, D. Berry, K. Wasmund, A. Schintlmeister, T. Boettcher, J.-X. Cheng, M. Wagner
This study shows that the Parkinson's drug entacapone disrupts gut microbiome homeostasis by sequestering iron, affecting microbial metabolism and promoting iron-scavenging organisms with resistance genes.
bioRxiv · Nov 12, 2023 · PreprintMicrobiology
J. Zhang, H. Lin, J. Xu, M. Zhang, X. Ge, C. Zhang, W. Huang, J.-X. Cheng
This paper introduces a high-throughput single-cell sorting platform using stimulated Raman-activated cell ejection, achieving high yield and purity in sorting polymer beads, bacteria, fungi, and tissue sections.
bioRxiv · Oct 16, 2023 · PreprintBioengineering
Z. Guo, G. Chiesa, J. Yin, A. Sanford, S. J. Meier, A. S. Khalil, J.-X. Cheng
This paper uses MIP microscopy to map the nanoscale secondary structure of huntingtin protein aggregates in live yeast cells, revealing a β-sheet core and α-helix shell, and shows prion-dependent structural differences.
bioRxiv · Oct 9, 2023 · PreprintBiophysics
Y.-f. Pan, H. Zhao, Q.-y. Gou, P.-b. Shi, J.-h. Tian, Y. Feng, K. Li, W.-h. Yang, D. Wu, G. Tang, B. Zhang, Z. Ren, S. Peng, G.-y. Luo, S.-j. Le, , M. Shi
The paper analyzes the virome of 2,438 individual mosquitoes across China to reveal viral diversity, geographic hotspots, and the impact of host phylogeny on viral composition.
bioRxiv · Aug 28, 2023 · PreprintEcology
Y. Zhu, X. Ge, H. Ni, J. Yin, H. Lin, L. Wang, Y. Tan, C. V. Prabhu Dessai, Y. Li, X. Teng, J.-X. Cheng
This paper introduces a new spectroscopic imaging method that improves signal intensity by over 500-fold for chemical imaging.
bioRxiv · Mar 6, 2023 · PreprintBioengineering
J. Yin, M. Zhang, Y. Tan, Z. Guo, H. He, L. Lan, J.-X. Cheng
This paper introduces a single pulse photothermal microscope for video-rate mid-infrared imaging, enabling observation of lipid dynamics and mapping fat storage in living systems.
bioRxiv · Feb 27, 2023Bioengineering
M. Zhang, P.-T. Dong, H. E. Eldesouky, Y. Zhan, H. Lin, Z. Wang, E. A. Salama, S. Jusuf, C. Zong, Z. Chen, M. N. Seleem, J.-X. Cheng
This paper identifies ergosteryl ester accumulation as a metabolic signature of azole-resistant Candida albicans using fingerprint SRS imaging and demonstrates a dual therapeutic strategy to suppress its viability.
bioRxiv · Dec 9, 2022 · PreprintMicrobiology
J.-X. Cheng, C. Yang, C. Marar, Y. Jiang, Y. Li, L. Lan, N. Zheng
This paper introduces a microwave split-ring resonator that enables submillimeter precision neuromodulation by enhancing microwave field localization and efficiency for inhibiting neurons.
bioRxiv · Jul 22, 2022Bioengineering
J. Zhang, J. Shin, N. Tague, H. Lin, M. Zhang, X. Ge, W. Wong, M. Dunlop, J.-X. Cheng
The paper visualizes limonene synthesis metabolons in engineered E. coli using hyperspectral SRS microscopy and confirms colocalization with limonene synthase.
bioRxiv · Jun 30, 2022Biophysics
y. zhang, D. Jia, Q. Yang, Y. Xue, Y. Tan, Z. Guo, M. Zhang, L. Tian, J.-X. Cheng
This paper introduces MIP-FLF microscopy to enable fast, volumetric infrared spectroscopic imaging of living cells and organisms, revealing lipid metabolism changes in drug-resistant pancreatic cancer cells.
bioRxiv · Jun 24, 2022 · PreprintBiochemistry
G. Zhao, Y. Tan, H. Cardenas, D. Vayngart, H. Huang, Y. Wang, R. Keathley, J.-J. Wei, C. R. Ferreira, J.-X. Cheng, D. Matei
This study shows that the balance between saturated and unsaturated fatty acids, regulated by SCD, affects ovarian cancer cell survival and tumor progression, with UFAs protecting against ER stress-induced apoptosis.
bioRxiv · May 24, 2022 · PreprintCancer Biology
Z. Chen, F. Chen, H. J. Lee, M. Zhang, X. Yin, M. Dai, J.-X. Cheng
This study identifies LIPA as a key regulator of CE hydrolysis in cancer cells, showing that its inhibition suppresses metastasis via suppression of NF-κB signaling.
bioRxiv · Mar 11, 2022 · PreprintCancer Biology
P.-T. Dong, Y. Zhan, S. Jusuf, J. Hui, Z. Dagher, M. K. Mansour, J.-X. Cheng
This study shows that photoinactivating catalase in fungi makes them more susceptible to ROS and immune cells, offering a new approach to treat drug-resistant fungal infections.
bioRxiv · Aug 31, 2021Microbiology
X. Ge, F. C. Pereira, M. Mitteregger, D. Berry, M. Zhang, M. Wagner, J.-X. Cheng
The paper introduces SRS-FISH, a high-throughput imaging method to analyze microbial function at the single-cell level, showing Bacteroidales dominate sugar utilization but Clostridia outperform them in fucose foraging.
bioRxiv · Jul 23, 2021 · PreprintMicrobiology
P.-T. Dong, S. Jusuf, J. Hui, Y. Zhan, Y. Zhu, G. Y. Liu, J.-X. Cheng
This study shows that blue light inactivates catalase in bacteria, making them vulnerable to ROS and immune cells, and validates this in a mouse model.
bioRxiv · Jun 24, 2021Microbiology
J. Li, Y. Tan, G. Zhao, K.-C. Huang, H. Cardenas, D. Matei, J.-X. Cheng
The paper identifies metabolic reprogramming in platinum-resistant cancer cells from glycolysis to fatty acid uptake and beta-oxidation, showing a correlation with resistance and proposing a treatment strategy.
bioRxiv · May 17, 2021 · PreprintCancer Biology
Y. Wang, G. Zhao, S. Condello, H. Huang, H. Cardenas, E. Tanner, J.-J. Wei, Y. Ji, J. Li, Y. Tan, R. Davuluri, J.-X. Cheng, D. Matei
The paper identifies FZD7 as a marker of platinum-tolerant ovarian cancer cells that are susceptible to ferroptosis via the FZD7-β-catenin-Tp63-GPX4 pathway.
bioRxiv · May 28, 2020Cancer Biology
S. Shrivastava, H. J. Lee, J.-X. Cheng
The paper uses hyperspectral stimulated Raman spectroscopy to show that neuronal membrane thermodynamic state changes during action potentials, supporting the acoustic hypothesis.
bioRxiv · Apr 20, 2020 · PreprintBiophysics
S. Jusuf, P.-T. Dong, J. Hui, E. R. Ulloa, G. Y. Liu, J.-X. Cheng
This study shows that photobleaching granadaene in Streptococcus agalactiae reduces its virulence and increases antimicrobial susceptibility to antibiotics and macrophage killing.
bioRxiv · Mar 31, 2020Microbiology
J. Hui, P.-T. Dong, L. Liang, T. Mandal, J. Li, E. R. Ulloa, Y. Zhan, S. Jusuf, C. Zong, M. N. Seleem, G. Y. Liu, Q. Cui, J.-X. Cheng
This study uses photo-disassembly of membrane microdomains to restore antibiotic susceptibility in MRSA, enabling conventional antibiotics to inhibit resistance development.
bioRxiv · Sep 26, 2019Microbiology