M. Srivastava

Bat RNA viruses employ viral RHIMs orchestrating species-specific cell death programs linked to Z-RNA sensing and ZBP1-RIPK3 signaling

The paper identifies viral RHIMs in bat RNA viruses that regulate host cell death through Z-RNA sensing and ZBP1-RIPK3 signaling, revealing species-specific effects on human and bat cells.

Soluble VE-cadherin disrupts endothelial barrier function via VE-PTP/RhoA signalling

This study shows that soluble VE-cadherin fragments disrupt endothelial barrier function by interfering with VE-PTP/RhoA signaling in both in vitro and in vivo models.

On the incongruence of genotype-phenotype and fitness landscapes

This paper studies how selection for low or intermediate phenotypic values creates incongruence between genotype-phenotype and fitness landscapes, showing that fitness landscapes can be more rugged but still support adaptive evolution.

SUMO/deSUMOylation of the BRI1 brassinosteroid receptor modulates plant growth responses to temperature

This study identifies SUMOylation of the BRI1 receptor and shows that temperature elevation triggers its deSUMOylation, modulating BR signaling and plant growth responses.

MK2 Expression Promotes Non-Small Cell Lung Cancer Cell Death and Predicts Survival

This study shows MK2 promotes apoptosis in non-small cell lung cancer by facilitating caspase 3 nuclear translocation, and higher MK2 expression correlates with better patient survival.

A NANOG-pERK reciprocal regulatory circuit mediates Nanog autoregulation and ERK signaling dynamics.

Engineered chemotaxis core signaling units indicate a constrained kinase-off state

The paper investigates how engineered chemoreceptor complexes stabilize a kinase-off state by sequestering kinase and substrate domains, using multiple biophysical techniques.

C17orf53 defines a novel pathway involved in inter-strand crosslink repair

This study identifies C17orf53 as a novel gene involved in inter-strand crosslink repair, showing its role in DNA replication and repair factor loading.