Author

R. J. Garrigues

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:structural biology· 1

Frequent Co-Authors

B. L. Garcia· 3 shared J. M. Leong· 2 shared A. D. P. Pierce· 1 shared A. Dowdell· 1 shared B. Wager· 1 shared E. Gerlach· 1 shared J. D. Quinn· 1 shared J. T. Skare· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMicrobiology

B. L. Garcia

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Outer surface lipoproteins from the Lyme disease spirochete exploit the molecular switch mechanism of the complement protease C1s

R. J. Garrigues, S. Thomas, J. M. Leong, B. L. Garcia

This study identifies ElpB and ElpQ as lipoproteins from Borreliella burgdorferi that inhibit the classical complement pathway by blocking C4 cleavage through exosite binding on C1s.

bioRxiv · Aug 17, 2022Biochemistry

Lipoproteome screening of the Lyme disease agent identifies novel inhibitors of antibody-mediated complement killing

M. J. Pereira, B. Wager, R. J. Garrigues, E. Gerlach, J. D. Quinn, A. Dowdell, M. S. Osburne, W. R. Zuckert, P. Kraiczy, B. L. Garcia, J. M. Leong

This study identifies two B. burgdorferi lipoproteins that inhibit complement C1 proteases, providing a novel mechanism for antibody-mediated complement evasion.

bioRxiv · Sep 23, 2021Microbiology

A structural basis for inhibition of the complement initiator protease C1r by Lyme disease spirochetes

R. J. Garrigues, A. D. P. Pierce, M. Hammel, J. T. Skare, B. L. Garcia

This study identifies the structural mechanism by which BBK32 inhibits the classical complement pathway by binding and inactivating C1r.

bioRxiv · Jan 21, 2021Microbiology