Author

J. T. Skare

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:statistical model· 2 Assay:structural biology· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

B. L. Garcia· 2 shared A. D. P. Pierce· 1 shared A. M. Schulz· 1 shared A. Powell-Pierce· 1 shared B. Wager· 1 shared C. E. Booth· 1 shared D. Medina-Perez· 1 shared E. Troy· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMicrobiology

B. L. Garcia

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Conformational dynamics of C1r inhibitor proteins from Lyme disease and relapsing fever spirochetes

S. Roy, C. E. Booth, A. Powell-Pierce, A. M. Schulz, J. T. Skare, B. L. Garcia

This study reports the crystal structure of FbpC and uses molecular dynamics simulations to show conformational dynamics in borrelial C1r inhibitors, revealing structural plasticity in their anti-complement activity.

bioRxiv · Mar 1, 2023 · PreprintMicrobiology

A structural basis for inhibition of the complement initiator protease C1r by Lyme disease spirochetes

R. J. Garrigues, A. D. P. Pierce, M. Hammel, J. T. Skare, B. L. Garcia

This study identifies the structural mechanism by which BBK32 inhibits the classical complement pathway by binding and inactivating C1r.

bioRxiv · Jan 21, 2021Microbiology

The Intergenic Small Non-Coding RNA ittA is Required for Optimal Infectivity and Tissue Tropism in Borrelia burgdorferi

D. Medina-Perez, B. Wager, E. Troy, L. Gao, S. Norris, T. Lin, L. Hu, J. Hyde, M. Lybecker, J. T. Skare

This paper identifies and characterizes ittA, an intergenic sRNA in Borrelia burgdorferi, showing its role in infectivity and tissue tropism through genetic inactivation and transcriptomic/proteomic analyses.

PLOS Pathogens · May 4, 2020Peer-reviewedMicrobiology