Author

R. J. Karnes

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:multiome· 1

Frequent Co-Authors

D. Wang· 1 shared H. Huang· 1 shared I. Coleman· 1 shared J. Zhang· 1 shared L. Ding· 1 shared L. Ma· 1 shared L. Wang· 1 shared P. S. Nelson· 1 shared

Activity by Year

2018-2018 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

D. Wang

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1 paper

Recent·Most cited

EZH2 co-opts gain-of-function p53 mutants to promote cancer growth and metastasis

Y. Zhao, L. Ding, D. Wang, Z. Ye, Y. Pan, L. Ma, R. Coleman, I. Coleman, R. J. Karnes, J. Zhang, P. S. Nelson, L. Wang, R. Zhu, H. Huang

This study identifies EZH2 as a p53 mRNA-binding protein that enhances translation of gain-of-function p53 mutants, promoting cancer growth and metastasis, and shows that inhibiting EZH2 causes synthetic lethality in these cells.

bioRxiv · Apr 10, 2018Cancer Biology