Author

R. J. Pyron

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Approach:biophysical modeling· 1 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

F. N. Barrera· 2 shared A. Dixson· 1 shared A. Gray· 1 shared A. R. Sahoo· 1 shared A. W. Smith· 1 shared C. M. Russell· 1 shared D. Alves· 1 shared E. Conley· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

F. N. Barrera

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Author profile →

2 papers

Recent·Most cited

Allosteric inhibition of the epidermal growth factor receptor through disruption of transmembrane interactions

J. A. Rybak, A. R. Sahoo, S. Kim, R. J. Pyron, S. B. Pitts, S. Guleryuz, A. W. Smith, M. Buck, F. N. Barrera

This study develops a pH-responsive peptide, PET1, that inhibits EGFR-mediated cell migration by disrupting transmembrane interactions, offering a new strategy for targeting RTKs with reduced side effects.

bioRxiv · Oct 31, 2022Cell Biology

The C. albicans virulence factor Candidalysin polymerizes in solution to form membrane pores and damage epithelial cells.

C. M. Russell, K. Schaefer, A. Dixson, A. Gray, R. J. Pyron, D. Alves, N. Moore, E. Conley, T. White, T. Do, G. King, F. N. Barrera

This study reveals that Candidalysin polymerizes in solution to form membrane pores, damaging epithelial cells, and identifies polymerization as a therapeutic target for candidiasis.

bioRxiv · Nov 11, 2021 · PreprintBiophysics