A missense mutation dissociates triglyceride and phospholipid transfer activities in zebrafish and human microsomal triglyceride transfer protein
M. H. Wilson, S. Rajan, A. Danoff, R. J. White, M. R. Hensley, V. H. Quinlivan, J. H. Thierer, E. M. Busch-Nentwich, M. M. Hussain, S. A. Farber
This study identifies a missense mutation in MTP that separates triglyceride and phospholipid transfer activities, suggesting potential for selective therapeutic targeting of triglyceride transfer in dyslipidemia.
bioRxiv · Jul 22, 2019Physiology