Author

M. M. Hussain

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:mouse· 4 Assay:proteomics· 4 Organism:human· 3 Research Focus:differential expression· 2 Organism:zebrafish· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

B. Prakash· 2 shared J. H. Thierer· 2 shared M. H. Wilson· 2 shared P. K. Yadav· 2 shared S. A. Farber· 2 shared S. Rajan· 2 shared A. Ansari· 1 shared A. Christiano· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

B. Prakash

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Microsomal triglyceride transfer protein is necessary to maintain lipid homeostasis and retinal function

C. R. Grubaugh, A. Dhingra, B. Prakash, D. Montenegro, J. R. Sparrow, L. L. Daniele, C. A. Curcio, B. A. Bell, M. M. Hussain, K. Boesze-Battaglia

This study shows that RPE-specific MTP is essential for maintaining retinal lipid homeostasis and visual function, but not for plasma lipoprotein metabolism.

bioRxiv · Dec 6, 2023Cell Biology

FITM2 deficiency results in ER lipid accumulation, ER stress, reduced apolipoprotein B lipidation, and VLDL triglyceride secretion in vitro and in mouse liver

H. Wang, C. Nikain, J. Amengual, M. La Forest, Y. Yu, M. C. Wang, R. Watts, R. Lehner, Y. Qiu, M. Cai, I. J. Kurland, I. J. Goldberg, S. Rajan, M. M. Hussain, J. L. Brodsky, E. A. Fisher

This study shows FITM2 deficiency reduces VLDL triglyceride secretion and causes ER stress and lipid accumulation in liver cells and mice.

bioRxiv · Dec 5, 2023 · PreprintBiochemistry

MicroRNA-541-3p alters lipoproteins to reduce atherosclerosis by degrading Znf101 and Casz1 transcription factors

A. Ansari, P. K. Yadav, L. Zhou, B. Prakash, B. Gangula, L. Ijaz, A. Christiano, S. Ahmad, A. Rimbert, M. M. Hussain

This study identifies miR-541-3p as a regulator that reduces atherosclerosis by decreasing apoB and increasing apoA1 through degradation of Znf101 and Casz1 transcription factors.

bioRxiv · Nov 1, 2023 · PreprintPhysiology

Pla2g12b is Essential for Expansion of Nascent Lipoprotein Particles

J. H. Thierer, O. Foresti, P. K. Yadav, M. H. Wilson, T. Moll, M.-C. Shen, E. Busch-Nentwich, M. Morash, K. Mohlke, J. F. Rawls, V. Malhotra, M. M. Hussain, S. A. Farber

The paper identifies Pla2g12b as essential for lipid loading onto nascent triglyceride-rich lipoproteins, showing its role in TRL expansion and its impact on atherosclerosis resistance.

bioRxiv · Aug 2, 2022 · PreprintCell Biology

A missense mutation dissociates triglyceride and phospholipid transfer activities in zebrafish and human microsomal triglyceride transfer protein

M. H. Wilson, S. Rajan, A. Danoff, R. J. White, M. R. Hensley, V. H. Quinlivan, J. H. Thierer, E. M. Busch-Nentwich, M. M. Hussain, S. A. Farber

This study identifies a missense mutation in MTP that separates triglyceride and phospholipid transfer activities, suggesting potential for selective therapeutic targeting of triglyceride transfer in dyslipidemia.

bioRxiv · Jul 22, 2019Physiology