S. A. Farber

Paraoxonase-like APMAP maintains endoplasmic reticulum-associated lipid and lipoprotein homeostasis

This paper identifies APMAP as an ER-localized antioxidant that maintains lipid and lipoprotein homeostasis, with loss of APMAP causing ER stress, lipid droplet accumulation, and altered lipoprotein maturation across multiple organisms.

Fish Playpens: Method for raising individual juvenile zebrafish on a recirculating system for studies requiring repeated measures

The paper introduces a method to raise individual juvenile zebrafish in a recirculating system for experiments requiring repeated measures, showing growth comparable to conventional methods.

A high-cholesterol zebrafish diet promotes hypercholesterolemia and fasting-associated liver triglycerides accumulation

This study shows that a high-cholesterol diet in zebrafish leads to hypercholesterolemia and fasting-induced liver triglyceride accumulation, with lipid accumulation in adipocytes contributing to hepatic steatosis.

Pla2g12b is Essential for Expansion of Nascent Lipoprotein Particles

The paper identifies Pla2g12b as essential for lipid loading onto nascent triglyceride-rich lipoproteins, showing its role in TRL expansion and its impact on atherosclerosis resistance.

Imaging cytoplasmic lipid droplets in vivo with fluorescent perilipin 2 and perilipin 3 knockin zebrafish

This study develops zebrafish models with fluorescent perilipin 2 and 3 to visualize lipid droplets in vivo, revealing dynamic changes in perilipin composition after high-fat feeding.

A missense mutation dissociates triglyceride and phospholipid transfer activities in zebrafish and human microsomal triglyceride transfer protein

This study identifies a missense mutation in MTP that separates triglyceride and phospholipid transfer activities, suggesting potential for selective therapeutic targeting of triglyceride transfer in dyslipidemia.