Salinomycin inhibits epigenetic modulator EZH2 to enhance Death Receptors in Colon Cancer Stem Cells
A. K. Singh, A. Verma, A. Singh, R. K. Arya, S. Maheshwari, P. Chaturvedi, M. A. Nengroo, K. K. Saini, A. L. Vishwakarma, K. Singh, J. Sarkar, D. Datta
This study shows salinomycin inhibits EZH2 in colon CSCs, enhancing DR4/DR5 expression and reducing CSC traits, suggesting a therapeutic strategy combining TRAIL and EZH2 inhibitors.
bioRxiv · Feb 3, 2020Cancer Biology