P. Chaturvedi

PERK arm of UPR selectively regulates ferroptosis in colon cancer cells by modulating the expression of SLC7A11 (System Xc-)

This study shows that PERK inhibition reduces SLC7A11 expression and sensitizes colon cancer cells to ferroptosis, suggesting PERK inhibitors as potential therapeutics.

Effects of orally administered crofelemer on the incidence and severity of neratinib-induced diarrhea in female dogs

This study evaluates crofelemer's effectiveness in reducing neratinib-induced diarrhea in female dogs, showing a 30% reduction in incidence and severity without loperamide.

Proximity labelling allows to study novel factors in chloroplast development

The paper uses proximity labelling to identify novel components in chloroplast development in Arabidopsis seedlings.

Parallel Activation of Src and Hif1α Increases Localized Glycolytic ATP Generation for Re-assembly of Endothelial Adherens Junctions

This study shows that Src and Hif1α activation increases glycolytic ATP production near endothelial adherens junctions, facilitating their re-assembly after injury.

Enrichment of breast cancer stem cells following cytotoxic chemotherapy is mediated by hypoxia-inducible factors

This study shows that cytotoxic chemotherapy in TNBC increases BCSCs via HIFs, leading to relapse, and that HIF inhibitors can block this effect.

Computational modeling of virucidal inhibition mechanism for broad-spectrum antiviral nanoparticles and HPV16 capsid segments

The paper uses molecular dynamics simulations to reveal how sulfonated nanoparticles disrupt HPV16 capsid protein interfaces, leading to virucidal activity.

Antifungal activity of Conocephalum conicum(L) Dumort. (Marchantiophyta) against Fusarium oxysporum f. sp. lycopersici

This study evaluates the antifungal activity of Conocephalum conicum extracts against Fusarium oxysporum f. sp. lycopersici, finding significant inhibition and suggesting its potential as an eco-friendly biocontrol agent.

Salinomycin inhibits epigenetic modulator EZH2 to enhance Death Receptors in Colon Cancer Stem Cells

This study shows salinomycin inhibits EZH2 in colon CSCs, enhancing DR4/DR5 expression and reducing CSC traits, suggesting a therapeutic strategy combining TRAIL and EZH2 inhibitors.

CXCR4 intracellular protein regulates drug resistance and tumorigenic potential via modulating the expression of Death Receptor 5

The paper shows that intracellular CXCR4 protein, not its signaling, promotes drug resistance and tumorigenicity by downregulating DR5 through transcription factor modulation.

Versatile multi-transgene expression using improved BAC TG-EMBED toolkit, novel BAC episomes, and BAC-MAGIC

This paper extends the BAC TG-EMBED method to enable versatile, stable, and reproducible multi-transgene expression in mammalian cells using episomal and integrated BAC constructs.