Pancreatic adenocarcinoma human organoids share structural and genetic features with primary tumors
I. Romero Calvo, C. R. Weber, M. Ray, M. A. Brown, K. J. Kirby, R. K. Nandi, T. M. Long, S. M. Sparrow, A. V. Ugolkov, W. Qiang, Y. Zhang, T. M. Brunetti, H. L. Kindler, J. P. Segal, A. Rzhetsky, , K. P. White
This study shows that pancreatic cancer organoids closely match primary tumors in molecular features, genetic diversity, and drug responses, suggesting their use in personalized therapy prediction.
bioRxiv · Jun 8, 2018Cancer Biology