Author

M. A. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Microbiology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Assay:bulk RNA-seq· 5 Approach:experimental assay· 5 Research Focus:differential expression· 4 Assay:DNA methylation· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

B. Zhang· 3 shared J. L. Rokita· 3 shared A. P. Heath· 2 shared H. Ijaz· 2 shared J. L. Mason· 2 shared J. V. Lilly· 2 shared K. A. Cole· 2 shared L. Tauhid· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCancer Biology

B. Zhang

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

A proteogenomic surfaceome study identifies DLK1 as an immunotherapeutic target in neuroblastoma

A. K. Weiner, A. B. Radaoui, M. Tsang, D. Martinez, S. Sidoli, K. L. Conkrite, A. Delaidelli, A. Modi, J. L. Rokita, K. Patel, M. V. Lane, B. Zhang, C. Zhong, B. Ennis, D. P. Miller, , S. J. Diskin

This study identifies DLK1 as a potential immunotherapeutic target in neuroblastoma through integrative proteomic, transcriptomic, and epigenomic analysis.

bioRxiv · Dec 6, 2023 · PreprintCancer Biology

The Children's Brain Tumor Network (CBTN) - Accelerating Research in Pediatric Central Nervous System Tumors through Collaboration and Open Science

J. V. Lilly, J. L. Rokita, J. L. Mason, T. Patton, S. Stefankiewiz, D. Higgins, G. Trooskin, C. A. Larouci, K. Arya, E. Appert, A. P. Heath, Y. Zhu, M. A. Brown, B. Zhang, B. K. Farrow, , W. Rife

The paper describes the Children's Brain Tumor Network (CBTN), a consortium that collects and shares multi-omic data and biospecimens to advance research on pediatric brain tumors.

bioRxiv · Oct 14, 2022Cancer Biology

Direct laser writing of 3D electrodes on flexible substrates

M. A. Brown, K. M. Zappitelli, L. Singh, R. C. Yuan, M. A. Bemrose, V. Brogden, D. J. Miller, S. F. Cogan, T. J. Gardner

This paper introduces a method for fabricating high-aspect-ratio 3D microelectrode arrays on flexible substrates using direct laser writing and silicon thin-film processing for neural recording applications.

bioRxiv · Jun 7, 2022 · PreprintBioengineering

TCF7L2 Silencing Reprograms the 4D Nucleome of Colorectal Cancer Cells

M. A. Brown, G. A. Dotson, S. Ronquist, G. Emons, I. Rajapakse, T. Ried

This study shows that TCF4 silencing alters chromatin structure and gene expression in colorectal cancer cells, identifying EMT and E2F pathways as deregulated and c-JUN as a key transcription factor.

bioRxiv · May 12, 2020 · PreprintCancer Biology

Pediatric High Grade Glioma Resources From the Children’s Brain Tumor Tissue Consortium (CBTTC) and Pediatric Brain Tumor Atlas (PBTA)

H. Ijaz, M. P. Koptyra, K. S. Gaonkar, J. L. Rokita, V. P. Baubet, L. Tauhid, Y. Zhu, M. A. Brown, G. Lopez Garcia, B. Zhang, S. J. Diskin, Z. Vaksman, J. L. Mason, E. M. Appert, J. V. Lilly, , K. A. Cole

This paper describes a resource of pediatric high grade glioma (pHGG) data and biospecimens from the CBTTC and PBTA, including genomic, clinical, and imaging data, along with cell lines and tissue microarrays.

bioRxiv · May 31, 2019Cancer Biology

Shotgun metagenomics reveals an enrichment of potentially cross-reactive bacterial epitopes in ankylosing spondylitis patients, as well as the effects of TNFi therapy and the host’s genotype upon microbiome composition

J. Yin, P. R. Sternes, M. Wang, M. Morrison, J. Song, T. Li, L. Zhou, X. Wu, F. He, J. Zhu, M. A. Brown, H. Xu

The paper uses shotgun metagenomics to analyze the gut microbiome in AS patients, finding enriched bacterial epitopes linked to HLA-B27 and effects of TNFi therapy and host genotype on microbiome composition.

bioRxiv · Mar 8, 2019Microbiology

HLA alleles associated with risk of ankylosing spondylitis and rheumatoid arthritis influence the gut microbiome

M. Asquith, P. R. Sternes, M.-E. Costello, L. Karstens, S. Diamond, T. M. Martin, T. D. Spector, K.-A. le Cao, J. T. Rosenbaum, M. A. Brown

This study identifies HLA-B27 and HLA-DRB1 alleles associated with altered gut microbiome composition in healthy individuals, suggesting a role for these alleles in influencing microbiome dynamics linked to ankylosing spondylitis and rheumatoid arthritis.

bioRxiv · Mar 5, 2019Microbiology

Pancreatic adenocarcinoma human organoids share structural and genetic features with primary tumors

I. Romero Calvo, C. R. Weber, M. Ray, M. A. Brown, K. J. Kirby, R. K. Nandi, T. M. Long, S. M. Sparrow, A. V. Ugolkov, W. Qiang, Y. Zhang, T. M. Brunetti, H. L. Kindler, J. P. Segal, A. Rzhetsky, , K. P. White

This study shows that pancreatic cancer organoids closely match primary tumors in molecular features, genetic diversity, and drug responses, suggesting their use in personalized therapy prediction.

bioRxiv · Jun 8, 2018Cancer Biology