HIV-1 subtype C with PYxE insertion has enhanced binding of Gag-p6 to host cell protein ALIX and increased replication fitness
R. van Domselaar, D. T. Njenda, R. K. Rao, A. Sönnerborg, K. Singh, U. Neogi
This paper shows that HIV-1C with PYxE insertion enhances Gag-p6 binding to ALIX and increases replication fitness, reducing sensitivity to antiretroviral drugs.
bioRxiv · Jan 18, 2019Microbiology