U. Neogi

Excessive inflammatory and metabolic responses to acute SARS-CoV-2 infection are associated with a distinct gut microbiota composition

This study identifies distinct gut microbiota compositions and metabolic/cytokine profiles associated with severe outcomes in SARS-CoV-2 infection.

Deciphering the role of mucosal immune responses and cervicovaginal microbiome in resistance to HIV infection in HIV-exposed seronegative (HESN) women

This study identifies elevated antiviral cytokines, immunoglobulins, and specific immune cell subsets in HESN women, along with increased bacterial diversity and Gardnerella spp abundance in the cervicovaginal microbiome, suggesting protective mechanisms against HIV.

Implications of central carbon metabolism in SARS-CoV-2 replication and disease severity

This study investigates how SARS-CoV-2 affects central carbon metabolism in host cells and links metabolic changes to disease severity.

Cytotoxic lymphocytes target HIV-1 Gag through granzyme M-mediated cleavage

This study shows that granzyme M from cytotoxic lymphocytes cleaves HIV-1 Gag, potentially controlling infection without killing infected cells.

Type-I interferon signatures in SARS-CoV-2 infected Huh7 cells

This study identifies delayed and dysregulated type-I interferon signaling in SARS-CoV-2 infected Huh7 cells and shows that IFN-I pretreatment reduces susceptibility.

Multi-omics insights into host-viral response and pathogenesis in Crimean-Congo Hemorrhagic Fever Viruses for novel therapeutic target

This study uses multi-omics approaches to analyze host-viral interactions in CCHFV infection, identifying metabolic reprogramming and interferon-mediated antiviral mechanisms as potential therapeutic targets.

Tropism of SARS-CoV-2 in commonly used laboratory cell lines and their proteomic landscape during infection

This study assesses SARS-CoV-2 tropism and proteomic changes in human cell lines, finding cell-type-specific susceptibility and interferon signaling dysregulation.

Distinct lipid profile, low-level inflammation and increased antioxidant defense as a signature in HIV-1 elite control status

This study identifies a distinct lipid profile, reduced inflammation, and increased antioxidant defense in HIV-1 elite controllers compared to viremic progressors and healthy controls.

Dysregulation in mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells

The paper identifies dysregulation in mTOR/HIF-1 signaling in SARS-CoV-2 infected cells through proteo-transcriptomics analysis.

Systemic inflammation and risk of age-associated diseases in people living with HIV on long term suppressive antiretroviral therapy

This study evaluates systemic inflammation and age-associated disease risk in HIV-positive individuals on long-term ART, finding persistent inflammation and telomere shortening despite viral suppression.

HIV-1 subtype C with PYxE insertion has enhanced binding of Gag-p6 to host cell protein ALIX and increased replication fitness

This paper shows that HIV-1C with PYxE insertion enhances Gag-p6 binding to ALIX and increases replication fitness, reducing sensitivity to antiretroviral drugs.