Dual Inhibition of Cathepsin L and 3CL-Pro by GC-376 Constrains SARS Cov2 Infection Including Omicron Variant
B. S. Prabhakar, P. Kumar, K. Ratia, J. M. Richner, G. R. J. Thatcher, R. Kadam, S. P. Smieszek, B. P. Przychodzen, V. Koprivica, G. Birznieks, M. H. Polymeropoulos
This study shows that dual inhibition of cathepsin-L and 3CL-Pro by GC-376 effectively inhibits SARS-CoV-2 infection, including the Omicron variant, in highly susceptible cell lines.
bioRxiv · Feb 9, 2022 · PreprintMicrobiology