Author

M. T. Woodside

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:virus· 3 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

M. Zhao· 4 shared D. B. Ritchie· 3 shared K. Neupane· 3 shared S. M. Ileperuma· 3 shared S. Munshi· 3 shared A. Lyons· 2 shared M. T. Halma· 2 shared A. Narayan· 1 shared

Activity by Year

2020-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersBiophysics

M. Zhao

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Quantifying oligomer populations in real time during protein aggregation using single-molecule mass photometry

S. S. Paul, A. Lyons, R. Kirchner, M. T. Woodside

This study uses single-molecule mass photometry to track oligomer populations during protein aggregation, revealing kinetic models and rate constants for tau protein aggregation.

bioRxiv · Jun 15, 2022Biophysics

Small-molecule ligands can inhibit -1 programmed ribosomal frameshifting in a broad spectrum of coronaviruses

S. Munshi, K. Neupane, S. M. Ileperuma, M. T. Halma, J. A. Kelly, C. F. Halpern, J. D. Dinman, S. Loerch, M. T. Woodside

The paper tests small-molecule ligands against -1 PRF in coronaviruses, finding nafamostat inhibits frameshifting in multiple bat CoVs and SARS-CoV-2 but not other viruses.

bioRxiv · Aug 6, 2021 · PreprintBiochemistry

Structural dynamics of the SARS-CoV-2 frameshift-stimulatory pseudoknot reveal topologically distinct conformers

K. Neupane, M. Zhao, A. Lyons, S. Munshi, S. M. Ileperuma, D. B. Ritchie, N. Q. Hoffer, A. Narayan, M. T. Woodside

The paper investigates the structural dynamics of the SARS-CoV-2 frameshift-stimulatory pseudoknot under tension, revealing multiple conformers and their folding mechanisms.

bioRxiv · Dec 28, 2020Biophysics

Conformational Shannon entropy of mRNA structures from force spectroscopy measurements predicts the efficiency of -1 programmed ribosomal frameshift stimulation

M. T. Halma, D. B. Ritchie, M. T. Woodside

The paper shows that -1 PRF efficiency correlates with the conformational heterogeneity of mRNA structures, measured as Shannon entropy, and this correlation depends on force.

bioRxiv · Dec 12, 2020Biophysics

Mechanically stable knot formed by strand threading in Zika virus RNA confers RNase resistance

M. Zhao, M. T. Woodside

The paper identifies a mechanically stable knot in Zika virus RNA that enhances RNase resistance through specific folding mechanisms.

bioRxiv · Jul 1, 2020 · PreprintBiophysics

Anti-frameshifting ligand active against SARS coronavirus-2 is resistant to natural mutations of the frameshift-stimulatory pseudoknot

K. Neupane, S. Munshi, M. Zhao, D. B. Ritchie, S. M. Ileperuma, M. T. Woodside

The paper examines how natural mutations in the SARS-CoV-2 pseudoknot affect −1 PRF efficiency and the activity of anti-frameshifting ligands, finding that ligand activity remains resistant to most mutations.

bioRxiv · Jun 29, 2020Biochemistry

Modeling the structure of the frameshift stimulatory pseudoknot in SARS-CoV-2 reveals multiple possible conformers

S. I. Omar, M. Zhao, R. V. Sekar, S. A. Moghadam, J. A. Tuszynski, M. T. Woodside

The paper models the structure of the SARS-CoV-2 frameshift stimulatory pseudoknot using computational methods and simulations, identifying multiple possible conformations.

bioRxiv · Jun 8, 2020Biophysics