Author

R. König

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:genetic perturbation / CRISPR· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

A. Oo· 2 shared B. Kim· 2 shared K. Schott· 2 shared M. Schüssler· 2 shared N. V. Fuchs· 2 shared P. Rauch· 2 shared A. Hiemisch· 1 shared A. L. Vera-Guapi· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

A. Oo

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction and cellular dNTP levels

M. Schüssler, K. Schott, N. V. Fuchs, A. Oo, M. Zahadi, P. Rauch, B. Kim, R. König

This study uses CRISPR/Cas9 to edit SAMHD1 in macrophage-like cells, revealing that T592 phosphorylation affects HIV-1 restriction and dNTP levels independently.

bioRxiv · Aug 24, 2023Microbiology

Machine learning on large scale perturbation screens for SARS-CoV-2 host factors identifies β-catenin/CBP inhibitor PRI-724 as a potent antiviral

M. A. Kelch, A. L. Vera-Guapi, T. Beder, M. Oswald, A. Hiemisch, N. Beil, P. Wajda, S. Ciesek, H. Erfle, T. Toptan, R. König

This paper uses machine learning on perturbation screens to identify PRI-724 as a potent antiviral targeting β-catenin/CBP, effective against multiple coronaviruses and influenza.

bioRxiv · Feb 23, 2023 · PreprintMicrobiology

CRISPR/Cas9 knock-in strategy to evaluate phospho-regulation of SAMHD1

M. Schüssler, P. Rauch, K. Schott, A. Oo, N. V. Fuchs, B. Kim, R. König

This study uses CRISPR/Cas9 knock-in to show that T592 dephosphorylation is required for SAMHD1's anti-viral activity, but not for dNTP depletion, suggesting uncoupling of these functions.

bioRxiv · Jan 4, 2022 · PreprintMicrobiology