Author

T. Toptan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

S. Ciesek· 4 shared D. Bojkova· 2 shared M. Widera· 2 shared A. Berger· 1 shared A. Hiemisch· 1 shared A. L. Siemund· 1 shared A. L. Vera-Guapi· 1 shared A. Pfeiffer· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

S. Ciesek

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Machine learning on large scale perturbation screens for SARS-CoV-2 host factors identifies β-catenin/CBP inhibitor PRI-724 as a potent antiviral

M. A. Kelch, A. L. Vera-Guapi, T. Beder, M. Oswald, A. Hiemisch, N. Beil, P. Wajda, S. Ciesek, H. Erfle, T. Toptan, R. König

This paper uses machine learning on perturbation screens to identify PRI-724 as a potent antiviral targeting β-catenin/CBP, effective against multiple coronaviruses and influenza.

bioRxiv · Feb 23, 2023 · PreprintMicrobiology

Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform

D. Bojkova, P. Reus, L. Panosch, M. Bechtel, T. Rothenburger, J. Kandler, A. Pfeiffer, J. U. Wagner, M. Shumliakivska, S. Dimmeler, R. Olmer, U. Martin, F. Vondran, T. Toptan, F. Rothweiler, , J. Cinatl

This study develops a phenotypic screening platform using caspase 3/7 activity to identify antiviral compounds against SARS-CoV-2, including novel candidates and combinations.

bioRxiv · Jul 17, 2022Pharmacology & Toxicology

Generation of a Sleeping Beauty transposon-based cellular system for rapid and sensitive identification of SARS-CoV-2 host dependency and restriction factors

M. Widera, A. Wilhelm, T. Toptan, J. M. Raffel, E. Kowarz, F. Roesmann, A. L. Siemund, V. Luciano, M. Kuelp, J. Reis, S. Bracharz, C. Pallas, S. Ciesek, R. Marschalek

This paper develops a Sleeping Beauty transposon-based cell system for rapid and sensitive detection of SARS-CoV-2 infection and screening of host factors.

bioRxiv · Apr 27, 2021 · PreprintMicrobiology

Optimized qRT-PCR approach for the detection of intra- and extracellular SARS-CoV-2 RNAs

T. Toptan, S. Hoehl, S. Westhaus, D. Bojkova, A. Berger, B. Rotter, K. Hoffmeier, S. Ciesek, M. Widera

This study presents an optimized qRT-PCR method for detecting SARS-CoV-2 RNA using a low-cost SYBR green approach, showing improved detection limits and simplicity compared to multi-step assays.

bioRxiv · Apr 20, 2020Microbiology