Author

R. L. F. O'Brien

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:imaging· 2 Approach:microscopy & imaging analysis· 2 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. Kovacs· 1 shared D. C. Dunn· 1 shared D. F. Nixon· 1 shared J. M. Crater· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

4 top collaborators · 3 mutual co-author links

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1 shared paperImmunology

C. Kovacs

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintJul 27, 2023

A Subset of HIV 1 Controllers Lack Cortical Actin Disruption Indicative of ARP2/3 Inhibition.

R. L. F. O'Brien, C. Kovacs

The paper identifies that some HIV-1 controllers lack actin disruption typical of ARP2/3 inhibition, suggesting a protective mechanism against immune dysfunction.

DOI 10.1101/2023.07.27.550860

humanimaging

𝕏 PostBluesky

ImmunologybioRxivPreprintJul 27, 2023

HIV-1 Mediated Cortical Actin Disruption Mirrors ARP2/3 Defects Found in Primary T Cell Immunodeficiencies.

J. M. Crater, D. C. Dunn, D. F. Nixon, R. L. F. O'Brien

This study shows HIV-1 infection disrupts cortical actin in CD4+ T cells, mimicking ARP2/3 defects in immunodeficiencies, and identifies ARP2/3 as a potential therapeutic target.

DOI 10.1101/2023.07.27.550856

humanimaging

𝕏 PostBluesky