R. L. Heimark

Transcriptional regulation of SLIT2 expression in pancreatic cancer cell lines

This study investigates the transcriptional regulation of SLIT2 in pancreatic cancer cell lines, finding that its expression is epigenetically silenced by promoter methylation and histone modifications.

Cell intrinsic signaling in MEN1 mutant pancreatic neuroendocrine tumors unveils novel signaling pathways associated with de-differentiation

The paper identifies MEN1 and FGFR3 mutations in pancreatic neuroendocrine tumors and links them to de-differentiation and aggressiveness, suggesting FGFR3 as a therapeutic target.

Inhibition of Sphingosine-1-Phosphate signaling in pancreatic ductal adenocarcinoma leads to downregulation of growth and invasion

This study investigates the role of S1P signaling in pancreatic ductal adenocarcinoma, showing that its inhibition reduces growth and invasion.

mir-218 modulates ARF6 expression and inhibits pancreatic ductal adenocarcinoma invasion

This study identifies miR-218 as a suppressor of pancreatic ductal adenocarcinoma invasion by regulating ARF6 and inhibiting matrix degradation.

Identification and transcriptional regulation of the mir-218-1 alternative promoter

The paper identifies a novel transcriptional start site for mir-218-1 in pancreatic ductal adenocarcinoma and shows its regulation by NF-kB.