Author

A. Cardenas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 2 Microbiology· 2 Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 6 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:chromatin & epigenetic regulation· 3 Assay:DNA methylation· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2

Frequent Co-Authors

G. Sturm· 3 shared M. Hirano· 3 shared M. Picard· 3 shared S. Horvath· 3 shared B. A. Kaufman· 2 shared C. Bris· 2 shared J. Lin· 2 shared K. R. Karan· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

G. Sturm

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Neisseria gonorrhoeae scavenges host sialic acid for Siglec-mediated, complement-independent suppression of neutrophil activation

A. Cardenas, K. S. Thomas, M. W. Broden, N. J. Ferraro, C. John, M. M. Pires, G. A. Jarvis, A. K. Criss

This paper shows that Neisseria gonorrhoeae uses sialic acid from the host to modify its surface, which helps it avoid neutrophil activation without needing the complement system.

bioRxiv · Jan 17, 2024 · PreprintMicrobiology

OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases

G. Sturm, K. R. Karan, A. Monzel, B. S. Santhanham, T. Taivassalo, C. Bris, S. A. Duplaga, M. Cross, A. Towheed, A. Higgins-Chen, M. J. McManus, A. Cardenas, J. Lin, E. S. Epel, S. Rahman, , M. Picard

The paper shows that OxPhos dysfunction leads to hypermetabolism and reduced lifespan in cells and mitochondrial disease patients.

bioRxiv · Nov 29, 2021Cell Biology

A Multi-Omics and Bioenergetics Longitudinal Aging Dataset in Primary Human Fibroblasts with Mitochondrial Perturbations

G. Sturm, A. S. Monzel, K. R. Karan, J. Michelson, S. A. Ware, A. Cardenas, J. Lin, C. Bris, B. Santhanam, M. P. Murphy, M. E. Levine, S. Horvath, D. W. Belsky, S. Wang, V. Procaccio, , M. Picard

The paper presents a longitudinal multi-omics dataset of human fibroblasts with mitochondrial perturbations to study aging mechanisms and bioenergetics.

bioRxiv · Nov 12, 2021Cell Biology

Pancreatic cancer prognosis is predicted by a novel ATAC-array technology for assessing chromatin accessibility

S. Dhara, S. Chhangawala, H. Chintalapudi, G. Askan, V. Aveson, A. L. Massa, L. Zhang, A. P. Makohon-Moore, N. Lecomte, J. P. Melchor, J. Bermeo, A. Cardenas, S. Sinha, D. Glassman, R. Nicolle, , S. D. Leach

The paper develops ATAC-Array, a low-cost chromatin accessibility assay, and shows it predicts pancreatic cancer prognosis based on chromatin accessibility patterns.

bioRxiv · Jan 21, 2021Cancer Biology

Diatom Modulation of Microbial Consortia Through Use of Two Unique Secondary Metabolites

A. A. Shibl, A. Isaac, M. A. Ochsenkühn, A. Cardenas, C. Fei, G. Behringer, M. Arnoux, N. Drou, M. P. Santos, K. C. Gunsalus, C. R. Voolstra, S. A. Amin

This study shows diatoms use two unique secondary metabolites to promote beneficial bacteria and inhibit harmful ones in their microbial communities.

Proceedings of the National Academy of Sciences · Oct 16, 2020Peer-reviewedMicrobiology

Inhibition of Sphingosine-1-Phosphate signaling in pancreatic ductal adenocarcinoma leads to downregulation of growth and invasion

B. Rheinheimer, A. Cardenas, L. Camacho, E. S. Ong, T. Jie, R. L. Heimark

This study investigates the role of S1P signaling in pancreatic ductal adenocarcinoma, showing that its inhibition reduces growth and invasion.

bioRxiv · Sep 29, 2020 · PreprintCancer Biology

Dramatic shape changes occur as Cytochrome c folds

S. Kirmizialtin, F. Pitici, A. Cardenas, R. Elber, D. Thirumalai

The paper uses simulations to study Cytochrome c folding, showing dramatic shape changes from an unfolded prolate ellipsoid to a spherical native state through a sequential mechanism.

bioRxiv · Jun 25, 2020Biophysics

RNA interference of NADPH-Cytochrome P450 reductase increases susceptibilities to multiple acaricides in Tetranychus urticae

A. W. Adesanya, A. Cardenas, M. D. Lavine, D. B. Walsh, L. C. Lavine, F. Zhu

This study shows that RNA interference of NADPH-cytochrome P450 reductase (TuCPR) in Tetranychus urticae reduces resistance to multiple acaricides.

bioRxiv · Sep 24, 2019Pharmacology & Toxicology

Human Aging DNA Methylation Signatures are Conserved but Accelerated in Cultured Fibroblasts

G. Sturm, A. Cardenas, M.-A. Bind, S. Horvath, S. Wang, Y. Wang, S. Hagg, M. Hirano, M. Picard

bioRxiv · Apr 10, 2019Cell Biology