TGF-B signaling suppresses TCA cycle metabolism in renal cancer.
H. Nam, A. Kundu, S. Karki, G. Brinkley, D. S. Chandrashekar, R. L. Kirkman, J. Liu, M. V. Liberti, J. W. Locasale, T. Mitchell, S. Varambally, S. Sudarshan
This study shows that TGF-β signaling suppresses TCA cycle enzyme expression in renal cancer, leading to reduced mitochondrial metabolism and tumor growth.
bioRxiv · Feb 19, 2021 · PreprintCancer Biology