Author

J. W. Locasale

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Cell Biology· 3 Immunology· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 11 Assay:metabolomics· 9 Organism:human· 7 Organism:mouse· 6 Research Focus:cancer & tumor microenvironment· 5 Research Focus:cell signaling & trafficking· 5 Assay:proteomics· 5 Research Focus:metabolism & bioenergetics· 4

Frequent Co-Authors

J. Liu· 7 shared X. Liu· 3 shared Z. Dai· 3 shared D. G. Kirsch· 2 shared M. A. Reid· 2 shared M. V. Liberti· 2 shared S. M. Sanderson· 2 shared Z. Xiao· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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7 shared papersCancer Biology

J. Liu

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12 papers

Recent·Most cited

Methionine availability influences essential H3K36me3 dynamics during cell differentiation

Y. Sun, V. Ramesh, F. Wei, J. W. Locasale

This study shows methionine availability affects H3K36me3 dynamics and myogenic differentiation in mouse cells through the histone methyltransferase SETD2.

bioRxiv · Nov 22, 2023 · PreprintCell Biology

Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation

A. K. Meyers, Z. Wang, W. Han, Q. Zhao, M. Zabalawi, L. Duan, J. Liu, Q. Zhang, R. K. Manne, F. Lorenzo, M. A. Quinn, Q. Song, D. Fan, H.-K. Lin, C. M. Furdui, , X. Zhu

This study shows that inhibiting PDHK reduces NLRP3 inflammasome activation in macrophages, decreasing inflammation and tissue damage.

Cell Reports · Jan 1, 2023Peer-reviewedImmunology

Dietary methionine restriction impairs anti-tumor immunity through gut microbiota

M. Ji, X. Xu, Q. Xu, X. Xu, M. A. Azcarate-Peril, X. Wu, J. Liu, J. W. Locasale, J.-L. Li, I. Shats, X. Li

This study shows that dietary methionine restriction worsens cancer growth and reduces anti-tumor immunity via gut microbiota and immune suppression in immunocompetent mice.

bioRxiv · Aug 27, 2021 · PreprintCancer Biology

SGK1 Signaling Promotes Glucose Metabolism and Survival in Extracellular Matrix Detached Cells

J. A. Mason, J. A. Cockfield, D. J. Pape, H. Meissner, M. Sokolowski, T. C. White, J. C. Valentin Lopez, J. Liu, X. Liu, I. Martinez-Reyes, N. S. Chandel, J. W. Locasale, Z. T. Schafer

This study shows SGK1 promotes glucose metabolism and cell survival in ECM-detached cells by enhancing glucose uptake and PPP flux for ATP production.

Cell Reports · Mar 1, 2021Peer-reviewedCell Biology

TGF-B signaling suppresses TCA cycle metabolism in renal cancer.

H. Nam, A. Kundu, S. Karki, G. Brinkley, D. S. Chandrashekar, R. L. Kirkman, J. Liu, M. V. Liberti, J. W. Locasale, T. Mitchell, S. Varambally, S. Sudarshan

This study shows that TGF-β signaling suppresses TCA cycle enzyme expression in renal cancer, leading to reduced mitochondrial metabolism and tumor growth.

bioRxiv · Feb 19, 2021 · PreprintCancer Biology

Cellular Stress Signaling Activates Type-I IFN Response Through FOXO3-regulated Lamin Posttranslational Modification

I. Hwang, Z. Dai, F. Li, T. Sanchez, J. W. Locasale, L. L. Cantley, H. Zheng, J. Paik

The paper shows that oxidative stress in NSPCs activates the IFN-I response via FOXO3-regulated lamin modifications, preserving their regenerative potential.

bioRxiv · May 3, 2020Cell Biology

The Na+/K+ ATPase Regulates Glycolysis and Modifies Immune metabolism in Tumors

S. M. Sanderson, Z. Xiao, A. J. Wisdom, S. Bose, M. V. Liberti, M. A. Reid, E. Hocke, S. G. Gregory, D. G. Kirsch, J. W. Locasale

This study shows that Na+/K+ ATPase inhibition via digoxin disrupts glycolysis in tumor and healthy cells, alters immune metabolism, and changes tumor microenvironment composition.

bioRxiv · Mar 31, 2020 · PreprintCancer Biology

Dietary methionine restriction targets one carbon metabolism in humans and produces broad therapeutic responses in cancer

X. Gao, S. M. Sanderson, Z. Dai, M. A. Reid, D. E. Cooper, M. Lu, J. P. Richie, A. Ciccarella, A. Calcagnotto, P. Mikhael, S. J. Mentch, J. Liu, G. Ables, D. G. Kirsch, D. Hsu, , J. W. Locasale

This study shows that dietary methionine restriction affects one carbon metabolism in humans and produces therapeutic responses in cancer by altering metabolic pathways.

bioRxiv · May 4, 2019 · PreprintCancer Biology

Quantitative evaluation of a high resolution lipidomics platform

J. Liu, X. Liu, Z. Xiao, J. W. Locasale

The paper evaluates a high-resolution lipidomics platform that profiles lipids and polar metabolites, showing its ability to detect and quantify over 300 lipids and 300 metabolites with sensitivity and linear range analysis in cultured cells and metformin-treated ovarian cancer cells.

bioRxiv · May 4, 2019 · PreprintBiochemistry

NRF2-dependent metabolic reprogramming is required for tumor recurrence following oncogene inhibition

D. B. Fox, R. Lupo, L. C. Noteware, R. Newcomb, J. Liu, J. W. Locasale, M. D. Hirschey, J. V. Alvarez

This study identifies NRF2-driven metabolic reprogramming as essential for breast cancer recurrence after oncogene inhibition and shows it can be targeted with glutaminase inhibitors.

bioRxiv · Jan 8, 2019 · PreprintCancer Biology

Antigen receptor control of methionine metabolism in T cells

L. V. Sinclair, A. J. Howden, A. J. Brenes-Murillo, L. Spinelli, J. L. Hukelmann, A. N. Macintyre, X. Liu, S. Thomson, P. M. Taylor, J. C. Rathmell, J. W. Locasale, A. I. Lamond, D. A. Cantrell

This study shows antigen receptor engagement controls methionine cycle flux and methyl donor availability for RNA and histone methylation in T cells.

bioRxiv · Dec 18, 2018Immunology

Thermodynamic constraints on the regulation of metabolic fluxes

Z. Dai, J. W. Locasale

This study investigates how thermodynamics and enzyme activity regulate metabolic fluxes in pathways, showing that control is primarily determined by overall flux rather than individual enzymes or thermodynamics.

bioRxiv · Jun 7, 2018Biophysics