The allosteric activation of α7 nAChR by α-conotoxin MrIC is modified by mutations at the vestibular site
A. Gulsevin, R. L. Papke, C. Stokes, H. N. T. Tran, A.-H. Jin, I. Vetter, J. Meiler
This paper shows that α-conotoxin MrIC activates α7 nAChR allosterically through a vestibular site, confirmed by electrophysiology and computational docking.
bioRxiv · Apr 14, 2021Biophysics