A. Gulsevin

Evolutionarily diverse caveolins share a common structural framework built around amphipathic discs

The paper predicts structures for 73 caveolins across animal diversity and identifies conserved structural elements and amphipathic disc assembly, revealing an ancient structural framework predating Metazoa.

Template-free prediction of a new monotopic membrane protein fold and oligomeric assembly by Alphafold2

This study uses AlphaFold2 to predict the structure of caveolin-1, revealing its new fold and oligomeric assembly, but notes limitations in predicting higher-order complexes.

Structural characterization of a breast cancer-associated mutation in caveolin-1

This study examines how a breast cancer-associated mutation in CAV1, P132L, affects its structure and oligomerization, revealing its impact on caveolae formation.

First crystal structure of a non-canonical amino acid linked to a paramagnetic lanthanide tag facilitates protein structure determination using NMR-derived restraints

The paper presents the first crystal structure of a non-canonical amino acid linked to a paramagnetic lanthanide tag, showing how it improves NMR-derived structural modeling of proteins.

Molecular architecture of the human caveolin-1 complex

The paper uses cryo-electron microscopy to reveal the structure of the human caveolin-1 complex, showing it forms a disc with a flat membrane-binding surface.

Benchmarking Peptide Structure Prediction with AlphaFold2

This study benchmarks AlphaFold2's ability to predict peptide structures, finding it effective for some scaffolds but less so for peptides with kinks, turns, or flexible regions.

The allosteric activation of α7 nAChR by α-conotoxin MrIC is modified by mutations at the vestibular site

This paper shows that α-conotoxin MrIC activates α7 nAChR allosterically through a vestibular site, confirmed by electrophysiology and computational docking.

Prediction of amphipathic helix - membrane interactions with Rosetta

The paper develops AmphiScan, a Rosetta protocol to predict amphipathic helix-membrane interactions, achieving high accuracy in predicting coordinates and membrane-embedded residues.