Author

R. Lake

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Research Focus:cell type annotation· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

A. G. Sowalsky· 2 shared B. J. Capaldo· 2 shared A. Apolo· 1 shared A. Berger· 1 shared A. Hunt· 1 shared A. N. Alilin· 1 shared A. Sharma· 1 shared A. Singh· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

A. G. Sowalsky

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities

P. A. Desai, N. Takahashi, R. Kumar, S. Nichols, J. Malin, A. Hunt, C. Schultz, Y. Cao, D. Tillo, D. Nousome, L. Chauhan, L. Sciuto, K. Jordan, V. Rajapakse, D. Lissa, , R. El Meskini

This study maps the SCLC tumor microenvironment and identifies cancer-associated fibroblasts as key drivers of neuroendocrine state plasticity and poor prognosis.

bioRxiv · Feb 9, 2024Cancer Biology

The origin and dynamics of cellular heterogeneity vary across lineage subtypes of castrate resistant prostate cancer

M. L. Beshiri, B. J. Capaldo, R. Lake, A. T. Ku, D. Burner, C. M. Tice, C. Tran, J. Kostas, A. N. Alilin, J. Yin, S. Agarwal, S. A. Morris, F. H. Karzai, T. L. Lotan, W. L. Dahut, , K. Kelly

This study examines the origin and dynamics of cellular heterogeneity in different subtypes of castrate-resistant prostate cancer using patient-derived organoids and single-cell analyses, identifying distinct lineage plasticity patterns and therapeutic targets.

bioRxiv · Mar 24, 2022 · PreprintCancer Biology

MEIS1 down-regulation by MYC mediates prostate cancer development through elevated HOXB13 expression and AR activity

N. C. Whitlock, S. Y. Trostel, S. Wilkinson, N. T. Terrigino, S. T. Hennigan, R. Lake, N. V. Carrabba, R. Atway, E. D. Walton, B. E. Gryder, B. J. Capaldo, H. Ye, A. G. Sowalsky

This study shows that MYC down-regulates MEIS1 in prostate cancer, which increases AR activity and HOXB13 expression, promoting tumor development.

bioRxiv · Nov 20, 2019Cancer Biology