N. Takahashi

CD34-positive monocytes are highly susceptible to HIV-1

This study identifies CD34+ monocytes as highly susceptible to HIV-1 infection, showing they harbor more proviral DNA and express higher HIV-1 receptors despite cART.

Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities

This study maps the SCLC tumor microenvironment and identifies cancer-associated fibroblasts as key drivers of neuroendocrine state plasticity and poor prognosis.

Type 1 immunity enables neonatal thymic ILC1 production

The paper shows type 1 immunity drives thymic production and peripheral migration of ILC1s in neonates.

ATR inhibition augments the efficacy of lurbinectedin in small cell lung cancer

This study shows that combining ATR inhibition with lurbinectedin improves efficacy in SCLC, particularly in MYC-driven non-neuroendocrine tumors.

Local induction of IAA5 and IAA29 promotes DNA damage-triggered stem cell death in Arabidopsis roots

The paper shows that IAA5 and IAA29 promote DNA damage-triggered stem cell death in Arabidopsis roots by suppressing auxin signaling.

Subtyping of Small Cell Lung Cancer using plasma cell-free nucleosomes

This study uses cfChIP-seq on plasma samples to subtype SCLC based on epigenetic states, linking plasma nucleosome data to tumor transcriptomes and developing a classifier for lineage-defining transcription factors.

Computational analysis reveals similarities and differences between SCLC subtypes

The paper analyzes SCLC subtypes using gene expression data to determine their similarities and differences, identifying co-expressed modules and classifying cell lines into clusters.

Genome-wide association study of gastric cancer- and duodenal ulcer-derived Helicobacter pylori strains reveals discriminatory amino acid differences and novel oncoprotein candidates

This study uses GWAS to identify genetic variations in H. pylori strains associated with gastric cancer and duodenal ulcers, revealing amino acid differences and novel oncoprotein candidates.

DNA damage inhibits root growth by enhancing cytokinin biosynthesis in Arabidopsis thaliana.

This study shows DNA damage in Arabidopsis roots increases cytokinin synthesis, which suppresses auxin transport and reduces root growth.

The Arabidopsis NRT1/PTR FAMILY Protein NPF7.3/NRT1.5 is an Indole-3-butyric Acid Transporter Involved in Root Gravitropism

The paper identifies NPF7.3 as an IBA transporter involved in root gravitropism by facilitating IBA uptake, which is necessary for auxin gradient formation.

A mobile ELF4 delivers circadian temperature information from shoots to roots

This study identifies ELF4 as a mobile protein that transmits temperature signals from shoots to roots, regulating the root circadian clock based on temperature.

A regulatory module controlling stress-induced cell cycle arrest in Arabidopsis

This study identifies ANAC044 and ANAC085 as key regulators of DNA damage-induced G2 arrest in Arabidopsis, showing their role in enhancing Rep-MYB accumulation and cell cycle arrest under specific stress conditions.