Author

R. Lange

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1

Frequent Co-Authors

A. Mac Sweeney· 2 shared G. Bourquin· 2 shared M. Mueller· 2 shared N. Artico· 2 shared A. Chambovey· 1 shared A. Metz· 1 shared C. Joesch· 1 shared C. Lotz-Jenne· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

A. Mac Sweeney

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2 papers

Recent·Most cited

Discovery and binding mode of small molecule inhibitors of the apo form of human TDO2

C. Lotz-Jenne, R. Lange, S. Cren, G. Bourquin, L. Goglia, T. Kimmerlin, M. Wicki, M. Mueller, N. Artico, S. Ackerknecht, P. Pfaff, C. Joesch, A. Mac Sweeney

This study identifies small molecule inhibitors that bind to apo-TDO2 and inhibits its activity at low nanomolar concentrations, along with their co-crystal structures.

bioRxiv · Jan 9, 2024Biochemistry

Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket

C.-Y. Huang, A. Metz, R. Lange, N. Artico, C. Potot, J. Hazemann, M. Mueller, M. Dos Santos, A. Chambovey, D. Ritz, D. Eris, S. Meyer, G. Bourquin, M. E. Sharpe, A. Mac Sweeney

This study identifies 29 fragment hits against SARS-CoV-2 main protease using X-ray crystallography, including two covalent binders, and shows crystal form affects fragment binding poses.

bioRxiv · Nov 15, 2023Biophysics