Author

A. Metz

Primary ORCID profile (0000-0002-9634-9033 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

A. MetziD1 paper

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

A. Chambovey· 1 shared A. Mac Sweeney· 1 shared A.-N. Pelletier· 1 shared C. Potot· 1 shared C.-Y. Huang· 1 shared D. Eris· 1 shared D. Ritz· 1 shared F. U. Huschmann· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiophysics

A. Chambovey

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Single cell analysis reveals an antiviral network that controls Zika virus infection in human dendritic cells

K. M. Moore, A.-N. Pelletier, S. Lapp, A. Metz, G. K. Tharp, M. Lee, S. S. Bhasin, M. Bhasin, R.-P. Sekaly, S. E. Bosinger, M. S. Suthar

The paper uses scRNA-seq to analyze the antiviral response in human dendritic cells infected with ZIKV, identifying a network of host genes and proteins involved in antiviral defense.

bioRxiv · Jan 19, 2024Microbiology

Crystallographic fragment binding studies of the Mycobacterium tuberculosis trifunctional enzyme suggest binding pockets for the tails of the acyl-CoA substrates at its active sites and a potential substrate channeling path between them

S. Dalwani, A. Metz, F. U. Huschmann, M. S. Weiss, R. K. Wierenga, R. Venkatesan

bioRxiv · Jan 11, 2024 · PreprintBiochemistry

Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket

C.-Y. Huang, A. Metz, R. Lange, N. Artico, C. Potot, J. Hazemann, M. Mueller, M. Dos Santos, A. Chambovey, D. Ritz, D. Eris, S. Meyer, G. Bourquin, M. E. Sharpe, A. Mac Sweeney

This study identifies 29 fragment hits against SARS-CoV-2 main protease using X-ray crystallography, including two covalent binders, and shows crystal form affects fragment binding poses.

bioRxiv · Nov 15, 2023Biophysics