Author

M. E. Sharpe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:structural biology· 1 Organism:virus· 1

Frequent Co-Authors

A. Chaikuad· 1 shared A. Chambovey· 1 shared A. Mac Sweeney· 1 shared A. Metz· 1 shared C. Potot· 1 shared C.-Y. Huang· 1 shared D. Eris· 1 shared D. Merk· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

A. Chaikuad

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2 papers

Recent·Most cited

Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket

C.-Y. Huang, A. Metz, R. Lange, N. Artico, C. Potot, J. Hazemann, M. Mueller, M. Dos Santos, A. Chambovey, D. Ritz, D. Eris, S. Meyer, G. Bourquin, M. E. Sharpe, A. Mac Sweeney

This study identifies 29 fragment hits against SARS-CoV-2 main protease using X-ray crystallography, including two covalent binders, and shows crystal form affects fragment binding poses.

bioRxiv · Nov 15, 2023Biophysics

Structural insights into plasticity and discovery of remdesivir metabolite GS-441524 binding in SARS-CoV-2 macrodomain

X. Ni, M. Schroeder, V. Olieric, M. E. Sharpe, V. Olmos, E. Proschak, D. Merk, S. Knapp, A. Chaikuad

The paper reports crystal structures of SARS-CoV-2 nsP3 macrodomain bound to nucleotides and remdesivir metabolites, revealing structural plasticity and potential inhibitor targets.

bioRxiv · Mar 4, 2021Biochemistry