Cardiac myosin binding protein-C palmitoylation is associated with increased myofilament affinity, reduced myofilament Ca2+ sensitivity and is increased in ischaemic heart failure.
A. Main, G. N. Milburn, R. M. Balesar, A. C. Rankin, G. L. Smith, K. Campbell, G. S. Baillie, J. van der Velden, W. Fuller
This study identifies palmitoylation of cMyBP-C in cardiac myofilaments, showing it reduces Ca2+ sensitivity and is altered in heart failure.
bioRxiv · Jun 21, 2022 · PreprintCell Biology